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Itens para a visualização no momento 11-20 of 38
Disseleneto de difenila em modelos de infecção viral causada por herpes simplex vírus dos tipos 1 e 2
(Universidade Federal de Santa Maria, 2017-03-02)
Infectious diseases caused by herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are among the pathologies that most affect the population. The search for new therapeutic alternatives for its treatment becomes relevant ...
Propriedades antinociceptivas e antioxidantes do disseleneto de bis(fenilimidazoselenazolila) em roedores
(Universidade Federal de Santa Maria, 2016-11-07)
The current available drugs for treatment of disorders related to pain and inflammation present several adverse effects, then the investigation for novel molecules are required. It is known that organoselenium compounds ...
Ação neuroprotetora e anti-inflamatória do disseleneto de difenila e exercício de natação em modelo de envelhecimento em ratos
(Universidade Federal de Santa Maria, 2016-01-29)
Aging is a degenerative process that affects virtually all living organisms. The increase in the inflammatory process seems to be one of the main factors that contribute to aging and inflammaging and neuroinflammation in ...
Alterações sexo-específicas na memória e homeostase glutamatérgica induzidas por bisfenol A em camundongos: efeito do disseleneto de difenila
(Universidade Federal de Santa Maria, 2017-03-03)
Bisphenol A (BFA) is an endocrine disruptor with high toxicological potential, used in the manufacture of
synthetic polymers, including food and beverage packaging. Even though the deleterious effects of BPA
exposure ...
Ação farmacológica do 4,4’-dicloro-difenil disseleneto em modelos de hiperglicemia e obesidade em ratos
(Universidade Federal de Santa Maria, 2017-03-03)
The obesity epidemic is a worldwide public health problem and is considered one of the leading causes of death and disability worldwide. This is because the pathophysiology of this disease is extremely complex and involves ...
Desenvolvimento de nanocápsulas contendo disseleneto de bis (p-metoxifenila): biodistribuição e efeitos em modelos de dor em camundongos
(Universidade Federal de Santa Maria, 2017-08-11)
The chronic pain is a global public health problem and its pharmacological management is still unsatisfactory. The identification of novel molecules to effectively treat chronic pain states remains a major objective in ...
Estudo comparativo de β-selenoaminas e disselenetos em modelos hepatotóxico e alternativo
(Universidade Federal de Santa Maria, 2017-08-17)
Organic selenium compounds, Ebselen and diphenyl diselenide (DPDS), possess numerous characteristics such as, antioxidant activity, anti-inflammatory among others. In this regard, new molecules have been produced through ...
Avaliação dos efeitos de calcogenonucleosídeos derivados da zidovudina usando células sanguíneas como alvo toxicológico
(Universidade Federal de Santa Maria, 2018-02-23)
Zidovudine (AZT), a thymidine derivative, is widely used in antiretroviral regimens and more recently it has been indicated, in combination with other chemotherapeutics, for the treatment of some types of cancer. Patients ...
Disseleneto de m-trifluormetil-difenila modula as adaptações neurotóxicas e comportamentais induzidas pela retirada da morfina em camundongos
(Universidade Federal de Santa Maria, 2019-02-22)
Repeated use of morphine is controversial because it leads to the development of withdrawal syndrome, phenomenon involving a number of neuronal adaptations, which results on manifestations of physical signs and a state ...
Efeito do disseleneto de m-trifluormetil difenila em modelos de dor inflamatória aguda e subcrônica em camundongos
(Universidade Federal de Santa Maria, 2019-02-21)
The inflammation is a multicelular and complex process that has an essential protective role in the
body. However, it can become pathological when it acts with excessive intensity and prolong ...