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Síntese de (5-trifluormetil-1H-pirazol-1-IL)(quinolin-4-IL)metanonas de interesse farmacológico
(Universidade Federal de Santa Maria, 2016-07-22)
A convergent synthesis of a series of 16 new polysubstituted (5-hydroxy-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)(quinolin-4-yl)methanones, starting from isatin and alky(aryl/heteroaryl) ketones, is described. The ...
Síntese de 4,5-bis(trifluormetil)-1h-pirazóis através de reações eletrofílicas e nucleofílicas empregando NIS e MFSDA
(Universidade Federal de Santa Maria, 2019-02-27)
This dissertation describes the development of an efficient methodology for the functionalization of position 4 of 3-alkyl(aryl)-1-aryl-5-trifluoromethyl-1H-pyrazoles systems by halogenation and subsequent reaction with ...
1-(2,4-diclorofenil)-1H-pirazóis: síntese, análise estrutural e interação com os receptores canabinóides CB1
(Universidade Federal de Santa Maria, 2010-06-25)
A method to obtain fourteen enones [EtO2CC(O)C(R2)=C(R1)OR, where R = H, Me; R1 = Pr, Ph, 4-MeOC6H4, 4-MeC6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-NO2C6H4, Fur- 2-yl; R2 = H; R1,R2 = -(CH2)3-, -(CH2)4-, -(CH2)5-, -(CH2)6-, ...
Novos Espirocromenil-Trifluoretanonas a partir de Reações de Trifluoracetilação de Adutos de Kabbe e seus Espiro[diidrocromeno-cicloalcan]pirazóis e Isoxazóis Derivados
(Universidade Federal de Santa Maria, 2013-12-03)
This work describes firstly an efficient and regioselective method for the synthesis of a new series of 2,2,2-trifluoro-1-[4-methoxy-spiro(2H-chromen-2,1 -cycloalkan)-3-yl]ethanones from the Kabbe adducts (spiro[chroman-2,1 ...
Obtenção de novos heterociclos derivados do ácido levulínico
(Universidade Federal de Santa Maria, 2013-09-30)
This study describes the attainment of twenty three (23) bis-heterocycles derived from the Levulinic Acid: Bis-Pyrazoles (6a-k) by the reaction of cyclecondensation between the 3-(5-(trifluoromethyl)-4,5-dihydro-1H-pyraz ...
Obtenção regiosseletiva de 5-alquil(aril/heteroaril)-3- (carboxil/trifluormetil)-1h-1-fenilpirazóis
(Universidade Federal de Santa Maria, 2011-05-19)
This paper presents a new synthetic route for obtain regioselective 5-alkyl(aryl/heteroaryl)-3-trifluoromethyl-1H-1-phenylpyrazoles (3a-e) (50-85% yields) and 5-alkyl(aryl/heteroaryl)-3-carboxialkyl-1H-1-phenylpyrazoles ...
Síntese de [2]rotaxanos: relação entre a estrutura de pirazóis ligados ao filamento linear e a formação da molécula entrelaçada
(Universidade Federal de Santa Maria, 2015-02-25)
This work reports the synthesis of new [2]rotaxanes, [2]-[1,2-bis(aminocarbonyl-
(1'-(1',1'-dimethylethyl)-1H-pyrazol-3'-yl))-ethane]-rotaxa-1,7,14,20-tetraaza-
2,6,15,19-tetraoxo-3,5,912,16,18,22,25-tetrabenzocicloexacosano], ...
Síntese de Pirimidinas derivadas de 7,7,7-trialo-4-metoxi-6-oxo-4- heptenoatos de metila e bi-heterociclos trifluormetilados
(Universidade Federal de Santa Maria, 2012-02-27)
An efficient method to obtain pyrimidinones and pyrimidines trialomethylated from the cyclocondensation reaction of compounds of methyl 7,7,7-trihalo-4-methoxy-6-oxoheptenoate
with urea and differents amidines providing ...
Síntese de pirazóis e desenvolvimento de novos líquidos iônicos derivados de componentes farmacologicamente ativos
(Universidade Federal de Santa Maria, 2011-01-12)
The synthesis of two series of N-substituted pyrazoles from the cyclocondensation
reaction of β-enaminones ([R1C(O)C(R2)=CHN(Me2)], where R1 = Me, C6H5, 3-MeOC6H4,
4-Me-C6H4, 4-MeO-C6H4, 4-F-C6H4, 4-Cl-C6H4, 4-Br-C6H4, ...
Estudo de reações de flúor-inserção em 1H-pirazóis utilizando os reagentes fluorantes selectfluor, DAST e MFSDA
(Universidade Federal de Santa Maria, 2015-08-19)
This thesis describes the studies carried out using fluorinating reagents with different approaches: Selectfluor as an electrophilic fluorine source; DAST for nucleophilic fluorinations and MFSDA as a nucleophilic ...