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Compostos 1,2 e 1,4-dicarboxílicos atuam sobre o sistema glutamatérgico e o comportamento de ratos e camundongos
(Universidade Federal de Santa Maria, 2005-07-27)
Glutamatergic receptors are targets for many L-glutamate structure analogues, which cause neurotoxicity. This study investigated the actions of two dicarboxylic compounds, the first had cyclic framework and rigid structure, ...
Poliaminas modulam a memória nas tarefas de medo condicionado e esquiva inibitória em ratos
(Universidade Federal de Santa Maria, 2004-09-03)
The polyamines, spermine, spermidine and putrescine, are a group of aliphatic amines that interact with diverse cellular targets such as nucleic acids and proteins. The polyamines may act as physiological modulators of ...
Efeitos tóxicos do etanol e sua relação com o estresse oxidativo
(Universidade Federal de Santa Maria, 2005-08-12)
Ethanol is one of the most ingested substances among the different societies. So, it becomes target of several studies that intent to elucidate its mechanisms of toxicity. This study was aimed to better understand the link ...
Efeitos do disseleneto de difenila na atividade da enzima δ-aminolevulinato desidratase e em parâmetros bioquímicos de ratos com diabetes mellitus tipo 1
(Universidade Federal de Santa Maria, 2004-07-16)
The hyperglycemia and oxidative stress are factors strongly involved on development of many disorders that characterize the Diabetes Mellitus. It is known that some organic and inorganic selenium compounds are potent ...
Avaliação de parâmetros toxicológicos em piavas (Leporinus sp.) Expostas ao zinco e ao cobre
(Universidade Federal de Santa Maria, 2005-08-19)
The aim of this study was to verify the zinc and copper effects, metals frequently found in aquatic ecosystems, on the metabolism of piavas (Leporinus sp.). In this work, it was verified the average lethal concentrations ...
Efeito da diacereína sobre a febre induzida por suspensão de Saccharomyces cerevisiae e por prostaglandina e2 em ratos jovens
(Universidade Federal de Santa Maria, 2005-06-10)
Fever is a systemic response that results of a cascade of events that usually begins with pathogenic infection. Its development represents an important aspect of host defense that is mediated by the central nervous system. ...
Ditelureto de difenila induz prejuízos no desenvolvimento, neurotoxicidade e desmielinização no sistema nervoso central de filhotes de ratos wistar
(Universidade Federal de Santa Maria, 2009-11-20)
The purpose of this study was to investigate if myelinogenesis is related to the mechanism by which diphenyl ditelluride [(PhTe)2] causes toxicity in rat pups. The present study was performed to examine whether the behavioral ...
Agentes poliaminérgicos modulam a extinção do medo condicionado contextual em ratos
(Universidade Federal de Santa Maria, 2009-11-23)
Polyamines, such as spermidine and spermine, have been reported to improve memory retention through the activation of N-methyl-D-aspartate receptors (NMDAr).
However whether polyamine agonists and antagonists alter extinction ...
Sobre a excitotoxicidade induzida por glutamato em retina embrionária de pinto
(Universidade Federal de Santa Maria, 2004-08-20)
Excitotoxicity refers to the neurodegenerative process initiated by excessive activation of receptors for the neurotransmitter glutamate. This process is one of the
most extensively studied processes of neuronal cell death, ...
Efeitos do herbicida clomazone sobre parâmetros metabólicos e antioxidantes em jundiá (Rhamdia quelen)
(Universidade Federal de Santa Maria, 2004-09-10)
The objective of this study was to evaluate the effect of clomazone herbicide on metabolism of silver catfish (Rhamdia quelen). It was measured levels of lactate, protein and glucose (plasma), glycogen, protein and lactate ...