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Itens para a visualização no momento 21-30 of 42
O disseleneto de difenila protege o modelo Caenorhabditis elegans para a doença de huntington através da ativação antioxidantes reduzindo a agregação de proteínas
(Universidade Federal de Santa Maria, 2020-06-16)
Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disease with a distinct phenotype, including chorea and dystonia, incoordination, cognitive decline and behavioral difficulties. Characterized ...
Depressão e prejuízo de memória induzidos pela administração de estreptozotocina em camundongos: efeitos terapêuticos do disseleneto de p-clorodifenila
(Universidade Federal de Santa Maria, 2020-02-20)
Pre-diabetes and diabetes are metabolic diseases of heterogeneous etiopathology including defects in
the secretion and action of insulin, or both, the presence of hyperglycemia, glucose and insulin
intolerance, disorders ...
Depressão induzida pela administração de dexametasona em camundongos: efeitos terapêuticos do disseleneto de p-clorodifenila
(Universidade Federal de Santa Maria, 2020-02-19)
Different animal models already reported that the administration of DEX can induce phenotypic behaviors of depression and anxiety, as well as brain molecular changes. However, most studies report on the effects of DEX from ...
Caracterização dos genes que codificam selenoproteínas em peixe-zebra (Danio rerio)
(Universidade Federal de Santa Maria, 2020-02-21)
Selenoproteins are selenocysteine (Sec)-containing proteins that exhibit numerous physiological functions, including redox homeostasis maintenance, thyroid hormones metabolism, selenium transport and chaperone-like activities. ...
Síntese e atividades antioxidante e antitumoral de 5´-arilseleno azidotimidina
(Universidade Federal de Santa Maria, 2012-03-30)
The synthesis of compounds that use a nucleoside as the base structure, has an intense field application. Among these compounds, the most known nowadays is azydothymidine or zidovudine, a drug which was first synthesized ...
Envolvimento do sistema dopaminérgico na ação do tipo antidepressiva do fenilselenometil em camundongos fêmeas
(Universidade Federal de Santa Maria, 2013-08-05)
Depression affects millions of people of different ages, races, religions and income at some period of their lives. The etiology of most mood disorders, although not fully understood, has come into sharper focus in the ...
Envolvimento dos sistemas adenosinérgico e dopaminérgico no efeito antinociceptivo de um derivado do selenoesterol em modelos de nocicepção aguda em camundongos
(Universidade Federal de Santa Maria, 2014-08-01)
Pain is a complex, multifactorial and protective process essential to the preservation of the integrity of the organisms, but when it becomes persistent its presence is devastating, which considerably reduces the well-being ...
Avaliação dos efeitos farmacológico e toxicológico de 4- organocalcogeno-isoquinolinas
(Universidade Federal de Santa Maria, 2014-03-12)
Monoamine oxidase (MAO) is a target enzyme in the treatment of several
pathologies, being that new molecules which inhibit of a selective, potent and
reversible manner their isoforms and without adverse effects are ...
Avaliação dos efeitos de drogas anti-adenosinérgicas e do disseleneto de difenila no prejuízo da memória e estresse oxidativo relacionados ao envelhecimento
(Universidade Federal de Santa Maria, 2012-08-08)
Biological aging is gradual and progressive decline of physical functions that begin in adulthood and ends with death in almost all animals species. One of the most common features of aging is the reduced ability to learn ...
Avaliação do efeito do disseleneto de difenila na nocicepção induzida pela administração neonatal de glutamato monossódico em ratos
(Universidade Federal de Santa Maria, 2014-09-09)
Monosodium glutamate (MSG) has been the target of research due to its toxicological effects. Neonatal administration of MSG in animals can affect the morphological and electrophysiological organization of the brain, leading ...