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Itens para a visualização no momento 31-40 of 190
Toxicologia e farmacologia in vitro de novos compostos orgânicos de selênio e telúrio com atividade tipo tiol peroxidase
(Universidade Federal de Santa Maria, 2009-05-08)
Glutathione peroxidase (GPx; EC 1.11.1.9) is a well-known selenoenzyme that catalyzes the reduction of hydrogen peroxide and some organic hydroperoxides by glutathione (GSH) and protects lipid membranes and other cellular ...
Efeito neuroprotetor da creatina e avaliação dos parâmetros cinéticos da captação de glutamato induzidos pelo ácido glutárico no estriado de ratos
(Universidade Federal de Santa Maria, 2008-10-14)
Glutaric acidemia type I (GA-I) is an inborn error of metabolism (EIM) biochemically characterized by the main accumulation of glutaric acid (GA) and 3- hydroxyglutaric acid (3-OH-GA), and pathologically by a characteristic ...
Efeitos da Campomanesia xanthocarpa em parâmetros bioquímicos, hematológicos e de estresse oxidativo em pacientes hipercolestrolêmicos
(Universidade Federal de Santa Maria, 2009-11-16)
In Southern Brazil, the plant Campomanesia xanthocarpa Berg. (Myrtaceae), popularly known as guavirova , has been empirically used for its potential effect in reducing blood cholesterol levels. Since there are no scientific ...
Avaliação do potencial antinociceptivo e mecanismo de ação do 2-[5-triclorometil-5-hidroxi-3-fenil-4,5-dihidro-1hpirazol- 1-il] 4-(4 bromofenil)- 5 metiltiazol (b50) em camundongos
(Universidade Federal de Santa Maria, 2005-07-21)
Pain is a common symptom in the clinical practice. Therefore, novel analgesic drugs, with more favorable pharmacological properties have been searched. Previous studies from our group showed that the systemic administration ...
Estudo do potencial analgésico e antiinflamatório do 3-(4-fluorfenil)-5-trifluormetil-1h-1-tosilpirazol em modelos de dor em camundongos
(Universidade Federal de Santa Maria, 2009-12-18)
Pain is the most common complaint in the medical field and the identification of compounds that can effectively treat painful states without induction of side-effects remains a major challenge in biomedical research. The ...
Efeito de 2-aril(heteroaril)-4,5-diidro-1h-imidazóis sobre a atividade da enzima monoamina oxidase in vitro
(Universidade Federal de Santa Maria, 2008-08-05)
Monoamine oxidase (MAO) is a flavin adenine dinucleotide (FAD)-containing enzyme attached to the mitochondrial outer membrane of neurons, glia, and other cells. Its roles include regulation of the levels of biogenic and ...
Avaliação dos efeitos de compostos orgânicos de selênio e de telúrio sobre a integridade estrutural e funcional de células sangüíneas humanas
(Universidade Federal de Santa Maria, 2009-01-09)
In view of the need to expand the toxicologic studies of organochalcogens in biological systems, the aim of this study was to investigate the effect of exposure to
organic compounds of selenium (Se) and tellurium (Te) on ...
Interferência de vasodilatadores na hidrólise de nucleotídeos da adenina em plaquetas de pacientes hipertensos
(Universidade Federal de Santa Maria, 2009-01-19)
The thrombogenic process that affects the hypertensive patient is associated
with regulatory mechanisms present in the vascular endothelium. These mechanisms
involve the release of a endothelium-derived relaxing factor, ...
Análise das propriedades antioxidantes das oximas 3-(fenil hidrazona) butano-2-ona e butano-2,3-dionatiosemicarbazona
(Universidade Federal de Santa Maria, 2008-05-12)
Oximes are chemical compounds used to reactivate the inhibited acetylcholinesterase (AChE) enzyme by organophosphates (OPs). The OPs, besides classically recognized as AChE irreversible inhibitors, are also involved in the ...
Avaliação das alterações comportamentais, eletrencefalográficas e da oxidação protéica induzidas pela injeção intraestriatal de ácido propiônico em ratos.
(Universidade Federal de Santa Maria, 2005-08-05)
Propionic acid (PA) is found in high amounts in tissues of patients with propionic acidemia, an inherited disorder of amino acid and lipid metabolism caused by severe
deficiency of propionil-CoA-carboxylase activity. PA ...