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Avaliação do efeito do disseleneto de difenila na nocicepção induzida pela administração neonatal de glutamato monossódico em ratos
(Universidade Federal de Santa Maria, 2014-09-09)
Monosodium glutamate (MSG) has been the target of research due to its toxicological effects. Neonatal administration of MSG in animals can affect the morphological and electrophysiological organization of the brain, leading ...
Avaliação do efeito inibitório do composto orgânico de selênio ebselen na atividade da enzima acetilcolinesterase cerebral de ratos in vitro
(Universidade Federal de Santa Maria, 2015-02-27)
Acetylcholinesterase (AChE) is an important regulatory enzyme that modulates cholinergic synapses by hydrolysis of acetylcholine (ACh), a neurotransmitter involved in many biological processes, especially in memory and ...
Avaliação dos mecanismos envolvidos na ação antinociceptiva causada pelo seleneto vinílico bis substituído (SVBS) em camundongos
(Universidade Federal de Santa Maria, 2009-03-24)
The interest in organoselenium biochemistry and pharmacology has increased in the last two decades due to a variety of organoselenium compounds that possess biological activity. Accordingly, bis selenide is known as a safe ...
Atividade hipolipidêmica do disseleneto de difenila na hiperlipidemia induzida por Triton WR-1339 em camundongos
(Universidade Federal de Santa Maria, 2009-11-26)
In mammals, the liver plays a central role in whole-body lipid metabolism. Unfortunately, dysregulation of these pathways has been implicated in hyperlipidemias. In recent years, a significant association between the trace ...
Efeito do tipo antidepressivo do disseleneto de difenila em um modelo de depressão induzida por malation em ratos
(Universidade Federal de Santa Maria, 2010-04-01)
Organophosphorus (OP), among them malathion, are responsible for most of the poisonings reported annually in Brazil. In addition to symptoms of cholinergic
poisoning, the exposure to OP causes affective and cognitive ...
4,4'-dicloro-difenil disseleneto reverte o déficit de memória induzido pela corticosterona em camundongos
(Universidade Federal de Santa Maria, 2016-02-29)
Chronic stress or even a single serious traumatic experience may have a negative impact on cognitive function. In this sense, organic selenium compounds are molecules that arouse great interest because they have various ...
Selenito de sódio previne neurotoxicidade induzida por paraquat em peixe-zebra (Danio rerio)
(Universidade Federal de Santa Maria, 2016-08-26)
Considering the sodium selenite (Na2SeO3) antioxidant properties and the involvement of oxidative and nitrosative stress events in neurotoxicity induced by paraquat (PQ) herbicide, this study investigated the potential ...
Mecanismos envolvidos no efeito antioxidante do disseleneto de difenila no dano oxidativo causado pela exposição à fumaça do cigarro em ratos jovens
(Universidade Federal de Santa Maria, 2009-09-09)
Cigarette smoking is a complex mixture of many constituents identified, among them reactive substances (reactive oxygen and nitrogen species), which are capable of initiating or promoting oxidative damage. Lungs and brain ...
3-(4-Fluorofenilselenil)-2,5 difenilselenofeno produz ação do tipo-antidepressiva em diferentes modelos de depressão em camundongos
(Universidade Federal de Santa Maria, 2014-03-11)
Selenophenes are a promising class of heterocyclic selenium-containing compounds
presenting important pharmacological properties. Based on selenium well-described role on
mood regulation and since depression is a serious ...
Modelos de toxicidade da cisplatina em ratos adolescentes: papel protetor do disseleneto de difenila e do ebselen e avaliação da co-exposição ao estresse
(Universidade Federal de Santa Maria, 2022-04-19)
Cisplatin is a recommended chemotherapy drug for the treatment of pediatric and adult
neoplasms that, despite its wide use, is related to numerous serious adverse effects
such as neurotoxicity. In animal models using ...