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Envolvimento de mastócitos em um modelo de dor pós-operatória em camundongos
(Universidade Federal de Santa Maria, 2012-02-28)
Recent studies have indicated that nearly half of all surgical patients present a picture of moderate to severe pain what become important to understand the mechanisms involved postoperative pain to be better treat it. ...
Efeitos do exercício físico sobre a atividade de enzimas dos sistemas purinérgico e colinérgico em sangue de ratos hipertensos
(Universidade Federal de Santa Maria, 2014-08-29)
Hypertension is a multifactor clinical condition, which is accompanied by a low-grade
inflammation and alterations in platelet function. These modifications may be related to an
imbalance in the regulation of adenine ...
Modulação do sistema das poliaminas e bloqueio seletivo de correntes de K+ do tipo A reverte o dano cognitivo induzido por peptídeo β-amiloide25-35
(Universidade Federal de Santa Maria, 2013-11-18)
In Alzheimer s disease (AD), β-amyloid peptide (Aβ) has been linked with synaptic loss and cognitive dysfunction, albeit the precise mechanism remains unknown. An involvement of N-Methyl-D-Aspartate receptors (NMDAR) in ...
Avaliação do sistema purinérgico e colinérgico em córtex de ratos após hipóxia-isquemia neonatal
(Universidade Federal de Santa Maria, 2013-03-15)
Hypoxia-ischemia (HI) neonatal is a major cause of morbidity and mortality during the perinatal period and it is an important risk factor for the development of a number of human neurological disorders, such as cerebral ...
Efeito antinociceptivo da N-acetilcisteina e da vitamina E em modelos de nocicepção em roedores
(Universidade Federal de Santa Maria, 2014-05-08)
Recently, oxidative stress was indicated as modulator of nociceptive transmission at spinal cord, and that nitric oxide (NO) may activate the TRPV1 in vitro. As no protein thiol compounds (SH) are the main endogenous ...
Avaliação do potencial antioxidante e antibacteriano de Anacardium microcarpum e sua toxicidade em diferentes modelos biológicos in vitro
(Universidade Federal de Santa Maria, 2015-09-11)
Oxidative stress reflects an imbalance between the systemic manifestation of reactive species and a biological system s ability to readily detoxify the reactive intermediates or to repair the resulting damage. This condition ...
Efeito antinociceptivo, antiinflamatório e antioxidante da Aloe saponaria Haw em modelos de queimadura em ratos
(Universidade Federal de Santa Maria, 2013-12-19)
In Brazil, the plant Aloe saponaria Haw, popularly known as babosa pintadinha , has been empirically used for its potential effect on skin burn injury, there are no scientific data confirming its popular use. Thus, the ...
Os efeitos do ácido cafeico e do éster fenetil do ácido cafeico sobre as atividades da acetilcolinesterase e das ecto-nucleotidases em ratos
(Universidade Federal de Santa Maria, 2013-01-21)
Phenolic compouds and their derivatives constitute a leading family of natural compounds. Caffeic acid (CA) and
caffeic acid phenethyl ester (CAPE) are the important members of phenolic compound, sharing several ...
Associação entre o polimorfismo +3954 do gene da interleucina-1 beta, obesidade, LDL-oxidado e seu potencial efeito lipotóxico
(Universidade Federal de Santa Maria, 2012-03-06)
Obesity is a systemic low grade inflammation, that is associated to the increased production of
proinflammatory molecules by adipose tissue. Besides, the adiposity elevated induces cellular
apoptosis and release of a ...
Avaliação do potencial antinociceptivo da Mirabilis jalapa L. em camundongos
(Universidade Federal de Santa Maria, 2010-12-09)
The knowledge about the use of medicinal plants by the population contributed decisively to the modern therapy and the discovery of important mechanisms related to the process of transmission and treatment of pain. A plant ...