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Efeitos protetores do zinco sobre alterações comportamentais e bioquímicas induzidas pelo mercúrio em ratos jovens
(Universidade Federal de Santa Maria, 2009-12-21)
Mercury is a toxic element that induces biochemical, neurological and behavioral changes, which can persist for a long time after the metal exposure. The contamination by mercury continues being a serious problem of public ...
Avaliação do sistema purinérgico e colinérgico em córtex de ratos após hipóxia-isquemia neonatal
(Universidade Federal de Santa Maria, 2013-03-15)
Hypoxia-ischemia (HI) neonatal is a major cause of morbidity and mortality during the perinatal period and it is an important risk factor for the development of a number of human neurological disorders, such as cerebral ...
Os efeitos do ácido cafeico e do éster fenetil do ácido cafeico sobre as atividades da acetilcolinesterase e das ecto-nucleotidases em ratos
(Universidade Federal de Santa Maria, 2013-01-21)
Phenolic compouds and their derivatives constitute a leading family of natural compounds. Caffeic acid (CA) and
caffeic acid phenethyl ester (CAPE) are the important members of phenolic compound, sharing several ...
Avaliação do potencial antinociceptivo da Mirabilis jalapa L. em camundongos
(Universidade Federal de Santa Maria, 2010-12-09)
The knowledge about the use of medicinal plants by the population contributed decisively to the modern therapy and the discovery of important mechanisms related to the process of transmission and treatment of pain. A plant ...
Avaliação de novos compostos sobre a atividade de colinesterases em modelos in silico e in vitro
(Universidade Federal de Santa Maria, 2012-06-04)
The enzyme acetylcholinesterase (EC 3.1.1.7, AChE) is responsible to terminate acetylcholine activity in
the terminal nervous junctions with its effector organs or post-synaptic sites. The activity of this enzyme
could ...
Atividade da NTPDase, 5 -nucleotidase, acetilcolinesterase e níveis de peroxidação lipídica em ratos expostos ao cádmio e tratados com curcumina
(Universidade Federal de Santa Maria, 2014-10-15)
Cadmium (Cd) is one of the most toxic metals in relation to environmental contamination and human poisoning. This metal has a long biological half-life (10-30 years) and prolonged exposure to Cd has been associated with ...
Ditelureto de difenila induz prejuízos no desenvolvimento, neurotoxicidade e desmielinização no sistema nervoso central de filhotes de ratos wistar
(Universidade Federal de Santa Maria, 2009-11-20)
The purpose of this study was to investigate if myelinogenesis is related to the mechanism by which diphenyl ditelluride [(PhTe)2] causes toxicity in rat pups. The present study was performed to examine whether the behavioral ...
Sensibilidade da enzima acetilcolinesterase (e.c. 3.1.1.7) à nicotina in vitro e in vivo
(Universidade Federal de Santa Maria, 2005-08-18)
This work valued the sensibility of the acetylcholinesterase from different sources and brain regions at nicotine in vitro, and the effects of the acute and subchronic exposures at the alkaloid on the brain acetylcholinesterase ...
Efeito do resveratrol nos sistemas colinérgico e purinérgico em encéfalo de ratos diabéticos
(Universidade Federal de Santa Maria, 2009-03-13)
Diabetes mellitus is a major public health problem throughout the world. Besides the most common complications in the peripheral nervous system, diabetes may also cause a series of cognitive, structural and functional ...
Estudo do sistema purinérgico e colinérgico no encéfalo de animais submetidos à hipoperfusão encefálica crônica e ao ambiente enriquecido
(Universidade Federal de Santa Maria, 2016-08-19)
Chronic cerebral hypoperfusion (CCH) has frequently been associated with neurodegenerative diseases. A persistent reduction of cerebral blood flow (CBF) changes the neuronal homeostasis causing diffuse ischemic damage and ...