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Efeito farmacogenético e farmacogenômico do metotrexato na citotoxicidade de células mononucleares periféricas do sangue
(Universidade Federal de Santa Maria, 2014-07-18)
Methotrexate (MTX) is an antimetabolite drug analogue of folic acid with wide clinical application, used in high doses for the treatment of cancer and in low doses for the treatment of autoimmune diseases such as rheumatoid ...
Efeito do Hypericum perforatum em diferentes modelos de desordens motoras em ratos
(Universidade Federal de Santa Maria, 2013-02-26)
Abnormal movements are clinical symptoms present in neurodegenerative diseases, such
Parkinsonism , as well as Tardive dyskinesia. It is thought that unbalance in monoamine
levels with their consequent metabolism could ...
Efeito do óleo essencial de lippia alba nos parâmetros oxidativos do jundiá (Rhamdia quelen) exposto a diferentes concentrações de oxigênio
(Universidade Federal de Santa Maria, 2009-09-01)
Juvenile silver fish (Rhamdia quelen) were exposed to the essential oil of
Lippia alba (L. alba) and transported in plastic bags for different periods (5, 6 and 7
h) yielding final different oxygen levels. The biomarkers ...
Efeito do Harpagophytum procumbens sobre parâmetros de estresse oxidativo e a viabilidade celular in vitro
(Universidade Federal de Santa Maria, 2013-10-04)
Harpagophytum procumbens, known as devil's claw, is an African plant with numerous therapeutic effects, among which stands out for its powerful anti-inflammatory action, but the mechanism by which exerts its effect is not ...
Efeito de dose única de vitamina D nas concentrações séricas de citocinas em mulheres idosas na pós-menopausa
(Universidade Federal de Santa Maria, 2014-03-07)
Vitamin D is an important immunomodulator. Epidemiological studies have shown that vitamin D deficiency impairs the immune functions and participates in the pathogenesis of infectious and autoimmune diseases. Vitamin D ...
Efeito da dieta enriquecida com rutina sobre os parâmetros sanguíneos e biomarcadores oxidativos em jundiás (Rhamdia quelen)
(Universidade Federal de Santa Maria, 2014-08-14)
Silver catfish, Rhamdia quelen, is one of the most cultivated fish species in southern Brazil. Products destined for improving rearing and production of this species are required due to its importance for aquaculture. ...
Efeito da exposição aguda à fumonisina B1 nas convulsões induzidas por pentilenotetrazol em camundongos
(Universidade Federal de Santa Maria, 2014-07-24)
Mycotoxins are secondary metabolites, produced by fungi species of the genus Aspergillus,
Fusarium, Penicillium and Claviceps. The high incidence of toxicity is by ingestion of
contaminated plant products and by consuming ...
Desenvolvimento e validação de metodologia para avaliação de fosfato de sitagliptina
(Universidade Federal de Santa Maria, 2010-04-16)
Sitagliptin Phosphate is an oral anti-hyperglycemic belonging to a new class of
medicine used in type 2 diabetes treatment, the dipeptidyl dipetidase -4 (DPP-4) enzyme
inhibitors. This drug besides being safe and tolerated, ...
Eficácia da escada analgésica da organização mundial da saúde (OMS) em um modelo de síndrome dolorosa induzida por paclitaxel em ratos
(Universidade Federal de Santa Maria, 2014-04-09)
Paclitaxel use in cancer is limited by a painful syndrome characterized by acute and chronic phases and by the lack of efficacious therapies. Thus, we assessed the efficacy of analgesics used in the World Health Organization ...
Extrato de Bauhinia variegata possui efeito tipo-antidepressivo em camundongos com envolvimento do sistema monoaminérgico
(Universidade Federal de Santa Maria, 2015-04-10)
Depression is a psychiatric disorder that affects 2-15% of the world population. It is a heterogeneous neuropathology, it includes psychological, behavioral and physiological symptoms. Despite having several treatments for ...