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Avaliação do perfil oxidativo e da atividade de ectoenzimas em pacientes com neoplasia intra-epitelial cervical
(Universidade Federal de Santa Maria, 2008-08-22)
Uterine cancers are considered to be one of the most important malignant diseases of the female genital tract, preceded only by breast cancer. The tumor cells may produce oxidative disturbances as well as damage to the ...
Polimorfismo da Ala16Val MnSOD na hipercolesterolemia e sua associação com biomarcadores de inflamação e estresse oxidativo
(Universidade Federal de Santa Maria, 2010-03-11)
This study aimed to analyze the association between the genetic polymorphism of the manganese-dependent superoxide dismutase (Ala16Val MnSOD) and the oxidative and inflammatory markers in hypercholesterolemic and control ...
Estudo de mecanismos de toxicidade do metilmercúrio: papel protetor de flavonóides
(Universidade Federal de Santa Maria, 2010-08-12)
Methylmercury (MeHg) is an important environmental toxicant that may cause irreversible neurobehavioral and neuropsychological disorders in humans and experimental animals. The major mechanisms of MeHg-induced toxicity ...
Investigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinais
(Universidade Federal de Santa Maria, 2011-03-18)
Oxidative stress (OS) is involved in the development of several disorders involving the central nervous system, such as Alzheimer s disease (AD). Considering the limitations of current therapeutics for AD, there is still ...
Sistemas purinérgico e colinérgico e perfil oxidativo no encéfalo de roedores: influência do alumínio e de diferentes dietas
(Universidade Federal de Santa Maria, 2008-03-05)
In this study, the effects of Aluminium (Al) and of different diets, both individually and in association, were investigated through the determination of NTPDase, 5 -nucleotidase and acetylcholinesterase (AChE) activities ...
Efeitos do difenil disseleneto sobre a disfunção mitocondrial na insuficiência hepática aguda induzida por paracetamol em camundongos
(Universidade Federal de Santa Maria, 2015-02-26)
Acute liver failure (ALF) induced by acetaminophen (APAP) is a complex process associated
with glutathione (GSH) depletion, energetics metabolism changes and mitochondrial dysfunction,
resulting in the impairment of ...
Toxicidade do mercúrio em ratas virgens, gestantes e lactantes: efeito protetor do zinco e da N-acetilcisteína
(Universidade Federal de Santa Maria, 2016-07-15)
Mercury (Hg) is a divalent metal found liquid at room temperature without biological functions and anthropogenically released in industrial, agricultural activities and burning of fossil fuels. Toxic effects caused by ...
Envolvimento do sistema da tiorredoxina nas alterações induzidas pelo chumbo in vitro e in vivo: implicações na toxicidade do chumbo
(Universidade Federal de Santa Maria, 2011-11-30)
Oxidative stress is an important molecular mechanism of lead (Pb) toxicity. The thioredoxin
system (selenoenzyme thioredoxin reductase-TrxR, thioredoxin protein- Trx and NADPH) is essential
for the antioxidant defense ...
Atividade de ectoenzimas do sistema purinérgico e análise de biomarcadores inflamatórios e de estresse oxidativo em pacientes com câncer de pulmão
(Universidade Federal de Santa Maria, 2014-11-13)
Lung cancer has been considered a public health problem since it has become one of the most commonly diagnosed neoplastic diseases and one of the most lethal in the world. This spread of lung cancer in the world population ...
Efeitos do resveratrol, do suco de uva e do vinho tinto nos biomarcadores de estresse oxidativo e na atividade de ectoenzimas em ratos diabéticos
(Universidade Federal de Santa Maria, 2012-11-28)
Diabetes mellitus is a major public health problem throughout the world. The chronic hyperglycemia present in the diabetic state is associated with increase of oxidative stress, which has been appointed to play a central ...