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Infecção experimental por Herpesvírus bovino tipo 5 em coelhos: efeitos no sistema purinérgico e perfil oxidativo
(Universidade Federal de Santa Maria, 2015-02-12)
The neurological disorder caused by BoHV-5 replication in the brain of infected animals, in the acute phase, may not be associated with significant histological changes or a significant number of antigen-positive neurons. ...
Efeitos do difenil disseleneto sobre a disfunção mitocondrial na insuficiência hepática aguda induzida por paracetamol em camundongos
(Universidade Federal de Santa Maria, 2015-02-26)
Acute liver failure (ALF) induced by acetaminophen (APAP) is a complex process associated
with glutathione (GSH) depletion, energetics metabolism changes and mitochondrial dysfunction,
resulting in the impairment of ...
Toxicidade do mercúrio em ratas virgens, gestantes e lactantes: efeito protetor do zinco e da N-acetilcisteína
(Universidade Federal de Santa Maria, 2016-07-15)
Mercury (Hg) is a divalent metal found liquid at room temperature without biological functions and anthropogenically released in industrial, agricultural activities and burning of fossil fuels. Toxic effects caused by ...
Envolvimento do sistema da tiorredoxina nas alterações induzidas pelo chumbo in vitro e in vivo: implicações na toxicidade do chumbo
(Universidade Federal de Santa Maria, 2011-11-30)
Oxidative stress is an important molecular mechanism of lead (Pb) toxicity. The thioredoxin
system (selenoenzyme thioredoxin reductase-TrxR, thioredoxin protein- Trx and NADPH) is essential
for the antioxidant defense ...
Atividade de ectoenzimas do sistema purinérgico e análise de biomarcadores inflamatórios e de estresse oxidativo em pacientes com câncer de pulmão
(Universidade Federal de Santa Maria, 2014-11-13)
Lung cancer has been considered a public health problem since it has become one of the most commonly diagnosed neoplastic diseases and one of the most lethal in the world. This spread of lung cancer in the world population ...
Efeitos do resveratrol, do suco de uva e do vinho tinto nos biomarcadores de estresse oxidativo e na atividade de ectoenzimas em ratos diabéticos
(Universidade Federal de Santa Maria, 2012-11-28)
Diabetes mellitus is a major public health problem throughout the world. The chronic hyperglycemia present in the diabetic state is associated with increase of oxidative stress, which has been appointed to play a central ...
Efeitos metabólicos do consumo da castanha do Brasil (Bertholletia excelsa) em humanos saudáveis
(Universidade Federal de Santa Maria, 2014-02-25)
Brazil nut (Bertholletia excelsa, Lecythidaceae family) is the richest known food in selenium. Its consumption has demonstrated efficient in improving the lipid profile and the plasmatic selenium levels as well as to ...
Efeitos de dietas hiperglicídicas e hiperlipídicas sobre a peroxidação lipídica e a atividade da enzima deltaaminolevulinato desidratase em camundongos
(Universidade Federal de Santa Maria, 2004-12-01)
Chronic intake of diets containing high proportion of glucose, sucrose or fat
promotes the development of insulin resistance and type 2 Diabetes mellitus.
Furthermore, high levels of glucose can produce permanent chemical ...
Ação farmacológica do 3-alquinil selenofeno em modelos de convulsão em ratos jovens
(Universidade Federal de Santa Maria, 2012-03-02)
Seizures have important consequences in terms of mortality and quality of life of the affected population, being a risk factor for the development of cognitive and behavioral abnormalities. Considering the promising ...
Avaliação do potencial antioxidante e antibacteriano de Anacardium microcarpum e sua toxicidade em diferentes modelos biológicos in vitro
(Universidade Federal de Santa Maria, 2015-09-11)
Oxidative stress reflects an imbalance between the systemic manifestation of reactive species and a biological system s ability to readily detoxify the reactive intermediates or to repair the resulting damage. This condition ...