A entrega local de bisfosfonatos influencia a osseointegração de implantes de titânio?: uma revisão sistemática

Abstract

The aim of this study was to systematically review the influence of local delivered bisphosphonates on osseointegration of titanium implants in humans. For this, a search in health sciences databases (The Cochrane Library, PubMed­MEDLINE, ISI Web of Knowledge and SCOPUS) and grey literature (SIGLE Open Grey) was performed, including articles published until May 2016. A total of 673 articles were found and, after removing the duplicates, 396 had their titles and abstracts reviewed. The complete text of six studies was read and, of these, three met the inclusion criteria. Each article included in the analysis was submitted to a quality evaluation and level of evidence, and their data were extracted and tabulated. Despite the methodological differences, all articles presented positive results of osseointegration when a local bisphosphonate was used ­ the authors report greater stability and better survival rate of the implants and a reduced peri­implant bone loss when compared to the control groups. According to this systematic review, it was concluded that the local use of a bisphosphonate seems to benefit the osseointegration of titanium implants in humans. Nonetheless, it is suggested a greater standardization and methodological bias control in future researches in order to allow that stronger evidences might be produced.