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Associação entre o consumo de antocianinas e a prevenção de alterações cognitivas, neuroquímicas e inflamatórias nos modelos experimentais de desmielinização e de neuroinflamação em roedores
(Universidade Federal de Santa Maria, 2015-08-14)
Anthocyanins (ANT) are phytonutrients with antioxidant and neuroprotective properties. In this context, this study sought evidence of a possible protective effect of ANT on models of demyelination and neuroinflammation in ...
Efeitos da dieta suplementada com disseleneto de difenila sobre a toxicidade induzida por mercúrio em camundongos e peixes
(Universidade Federal de Santa Maria, 2019-01-18)
With the increase of industrial and agricultural activities, several contaminants are released into the environment. Contaminants such as mercury (Hg) can come from the use of agricultural practices, burning of fossil fuels ...
Avaliação do potencial antioxidante dos extratos aquoso e etanólico de Mentha pulegium, Uncaria tomentosa e Phyllanthus niruri frente às alterações induzidas por T-butil hidroperóxido em eritrócitos humanos in vitro
(Universidade Federal de Santa Maria, 2016-07-27)
The stone cruscher (Phyllanthus niruri), cat'sclaw (Uncaria tomentosa) and pennyroyal (Mentha pulegium)have been used by people to treat a variety of diseases associated with oxidative stress. In this study, we aimed to ...
Avaliação dos efeitos de uma formulação comercial contendo azadiractina em carpa comum
(Universidade Federal de Santa Maria, 2016-03-10)
Due to the impact caused by synthetic insecticides in the aquatic environment, natural compounds obtained from natural sources have been used in the attempt of minimizing environmental risks. The commercial product NeenMaxTM, ...
Estudo do potencial antioxidante da espécie Caryocar coriaceum Wittm. em modelos experimentais in vitro e in vivo
(Universidade Federal de Santa Maria, 2016-04-29)
Despite the diversity of species found in the National Araripe Forest, Ceará Cariri, there are few studies with Caryocar coriaceumWittm (C. coriaceum), a plant that produces a highly consumed fruit in regional cuisine. The ...
Disseleneto de difenila em modelos de infecção viral causada por herpes simplex vírus dos tipos 1 e 2
(Universidade Federal de Santa Maria, 2017-03-02)
Infectious diseases caused by herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are among the pathologies that most affect the population. The search for new therapeutic alternatives for its treatment becomes relevant ...
Caenorhabditis elegans como modelo experimental para estudos toxicológicos e farmacológicos dos extratos de Luehea divaricata e Paullinia cupana
(Universidade Federal de Santa Maria, 2016-03-16)
The nematode Caenorhabditis elegans is a valuable tool for toxicological and
pharmacological studies. Despite its simple body, the most part of its genes and signaling
pathways are similar to humans, and alterations in ...
Envolvimento dos sistemas purinérgico, colinérgico e estresse oxidativo nos distúrbios da tireoide: possível efeito protetor da quercetina
(Universidade Federal de Santa Maria, 2017-02-22)
Thyroid hormones modulate the metabolic pathways in the body and have important physiological
functions in the brain and vascular system. Changes in their production or distribution lead to disorders
such as hypothyroidism ...
Ação farmacológica do 4,4’-dicloro-difenil disseleneto em modelos de hiperglicemia e obesidade em ratos
(Universidade Federal de Santa Maria, 2017-03-03)
The obesity epidemic is a worldwide public health problem and is considered one of the leading causes of death and disability worldwide. This is because the pathophysiology of this disease is extremely complex and involves ...
Polimorfismo Ala16ValMnSOD na epilepsia: envolvimento dos marcadores inflamatórios, oxidativos e glicolipídicos
(Universidade Federal de Santa Maria, 2019-08-17)
Epilepsy is a neurological disease that affects around 1% of world population, with neurobiological, neurochemical, cognitive and psychological consequences. Despite of the good prognosis, there is a high proportion of ...