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Influência do exercício físico sobre parâmetros de dependência e recaída em ratos expostos à anfetamina: aspectos comportamentais e bioquímicos
(Universidade Federal de Santa Maria, 2015-02-10)
Amphetamine compounds and its derivatives are widely used in clinical medicine, but it is known that frames can cause dependence, tolerance and withdrawal. Furthermore, these drugs can alter metabolism and the functions ...
Influência do estresse em diferentes períodos iniciais da vida sobre o desenvolvimento de ansiedade e preferência por morfina em ratos
(Universidade Federal de Santa Maria, 2015-07-17)
Drug addiction has exerted a considerable impact on society, resulting in one of the biggest public health problems reaching different ethnic groups and social classes worldwide. Brazil is the largest consumer of opioid ...
Efeito toxicogenético do polimorfismo Ala16Val do gene MnSOD em leucócitos expostos in vitro ao metil mercúrio
(Universidade Federal de Santa Maria, 2012-03-19)
The environmental contamination by methyl mercury (MeHg) is a great health public problem in
some world regions like Amazonia. The MeHg toxic effects seem to be influenced by
environmental and genetic factors. However, ...
Perfil lipidíco, agregação plaquetária e atividade de ectoenzimas do sistema purinérgico em plaquetas de pacientes HIV positivos sob terapia antirretroviral
(Universidade Federal de Santa Maria, 2013-08-23)
HIV infection is characterized by continuous viral replication and depletion of
CD4 + T lymphocytes, leading to immunological changes and opportunistic
infections by pathogens. The use of antiretroviral therapy (ART) ...
Efeito da hesperidina sobre o déficit cognitivo e o sistema colinérgico de ratos submetidos a um modelo de demência esporádica do tipo alzheimer
(Universidade Federal de Santa Maria, 2017-10-16)
Alzheimer's disease (AD) is considered the main cause of dementia in the world and the search for new therapeutic interventions for its treatment is of great relevance. Preclinical studies suggest the use of hesperidin ...
Atividade antitumoral da berberina em células de neuroblastoma SH-SY5Y
(Universidade Federal de Santa Maria, 2017-02-23)
Neuroblastoma is the most common tumor found in the first year of life and represent 6% of the all childhood cancers. There is few options of treatment and the mortality is close to 21%, or exceeds 50% between the high ...
Mecanismo antitumoral da berberina em linhagem de células U87MG de glioblastoma multiforme
(Universidade Federal de Santa Maria, 2017-07-31)
Glioblastoma multiforme (GBM) is the most prevalent tumor among gliomas. GBM cells present high pleomorphism, with undifferentiated cells, with cellular atypia and high mitotic activity, being considered as incurable tumors ...
Avaliação da capacidade antioxidante in vitro de novos compostos mono e disseleneto
(Universidade Federal de Santa Maria, 2013-07-26)
The antioxidant action of organic selenium compounds, as well as ebselen and diphenyl diselenide (DPDS), is closely connected to its ability of generating the selenol group. (In) this study it was evaluated the in vitro ...
Estudo das propriedades antioxidantes de diferentes ftalocianinas
(Universidade Federal de Santa Maria, 2013-02-22)
Oxidative stress is believed to be involved in the etiology of several chronic diseases, including cardiovascular disease, diabetes, cancer, and neurodegenerative disorders. From this perspective, we have evaluated the ...
Associação do disseleneto de difenila e moduladores do sistema glutamatérgico frente ao dano oxidativo causado por ácido quinolínico
(Universidade Federal de Santa Maria, 2013-02-22)
Excessive formation of reactive oxygen species (ROS) and disruption of glutamate
uptake have been hypothesized as key mechanisms contributing to quinolinic acid (QA)-
induced toxicity. Thus, here we investigate if the ...