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Itens para a visualização no momento 11-20 of 38
Efeito do ácido cafeico e ácido cafeico fenetil éster em modelo de inflamação induzida por lipopolisacarídeo
(Universidade Federal de Santa Maria, 2016-08-05)
Peripheral inflammation is able to cause alterations in central nervous system (CNS) and lead to progression of neurodegenerative diseases. During neuroinflammatory process the activation of immune cells from the CNS and ...
Discinesia espontânea em ratos: possível participação de mecanismos oxidativos e dopaminérgicos
(Universidade Federal de Santa Maria, 2017-08-17)
Tardive dyskinesia is a movement disorder that develops as a result of prolonged use of antipsychotics, mainly the typical ones, in approximately 20% to 25% of patients and, as age increases, it afflicts about 50% of ...
Efeitos do consumo de sacarose sobre parâmetros metabólicos, desenvolvimentais e antioxidantes em Drosophila melanogaster: papel das plantas Syzygium cumini e Bauhinia forficata
(Universidade Federal de Santa Maria, 2014-03-14)
The fruit fly, Drosophila melanogaster, has been considered a suitable model organism for investigation of developmental/metabolic dysfunctions and therapeutic strategies. In this work Drosophila melanogaster larvae were ...
Estudo comparativo dos efeitos tóxicos induzidos por metil e etilmercúrio em Saccharomyces cerevisiae
(Universidade Federal de Santa Maria, 2016-09-02)
Mercury is a highly toxic metal found in environment mostly due to anthropological and industrial processes. Methylmercury (MeHg) originates from the methylation of inorganic mercury in aquatic environment and accumulates ...
Efeito toxicogenético do polimorfismo Ala16Val do gene MnSOD em leucócitos expostos in vitro ao metil mercúrio
(Universidade Federal de Santa Maria, 2012-03-19)
The environmental contamination by methyl mercury (MeHg) is a great health public problem in
some world regions like Amazonia. The MeHg toxic effects seem to be influenced by
environmental and genetic factors. However, ...
Atividade antitumoral da berberina em células de neuroblastoma SH-SY5Y
(Universidade Federal de Santa Maria, 2017-02-23)
Neuroblastoma is the most common tumor found in the first year of life and represent 6% of the all childhood cancers. There is few options of treatment and the mortality is close to 21%, or exceeds 50% between the high ...
Associação do disseleneto de difenila e moduladores do sistema glutamatérgico frente ao dano oxidativo causado por ácido quinolínico
(Universidade Federal de Santa Maria, 2013-02-22)
Excessive formation of reactive oxygen species (ROS) and disruption of glutamate
uptake have been hypothesized as key mechanisms contributing to quinolinic acid (QA)-
induced toxicity. Thus, here we investigate if the ...
Efeito do decocto de Bauhinia forficata sobre parâmetros comportamentais e metabólicos em ratos tratados com haloperidol
(Universidade Federal de Santa Maria, 2012-09-27)
Schizophrenia is a psychiatric disorder that affects 1% of world population and its pharmacologic treatment consists in the use of antipsychotics. It is known that chronic treatment with classical antipsychotics, such as ...
Atividade de ectoenzimas e de colinesterases e biomarcadores de estresse oxidativo em pacientes com câncer de pulmão
(Universidade Federal de Santa Maria, 2012-03-02)
Lung cancer has become one of the most commonly diagnosed neoplastic diseases, as well as one of the most lethal worldwide, characterized, therefore, as a public health problem. This spread of lung cancer in the world ...
Efeitos do disseleneto de difenila sobre o dano oxidativo causado por paracetamol em cérebro de camundongos
(Universidade Federal de Santa Maria, 2012-06-11)
Acetaminophen (APAP) is the analgesic most used in world, in therapeutic doses does not show toxicity, but in elevated doses can cause hepatic damage due the formation of his metabolic toxic N-acetyl-p-benzoquinonimine ...