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Efeito toxicogenético do polimorfismo Ala16Val do gene MnSOD em leucócitos expostos in vitro ao metil mercúrio
(Universidade Federal de Santa Maria, 2012-03-19)
The environmental contamination by methyl mercury (MeHg) is a great health public problem in
some world regions like Amazonia. The MeHg toxic effects seem to be influenced by
environmental and genetic factors. However, ...
Efeito da rutina e da curcumina em marcadores inflamatórios e oxidativos em modelo experimental de hiperlipidemia
(Universidade Federal de Santa Maria, 2019-02-28)
Hyperlipidemia is characterized by lipid abnormalities that result in inflammation and
oxidative damage, factors involved in the development of atherosclerosis. Adenosine and
adenosine deaminase (ADA) modulate ...
Contribuição do sistema colinérgico e da sinalização do NRF2/HO-1 para a ação anti-amnésica do 7-flúor-1,3- difenilisoquinolina-1-amina em camundongos
(Universidade Federal de Santa Maria, 2019-07-26)
Dementia is a heterogenic condition characterized by different symptoms and theories about its pathogenesis, which results in difficult to understand and in the treatment of this disease. The 7-fluoro-1,3-diphenylisoquin ...
Efeito anti-inflamatório do ácido cafeico sobre o sistema purinérgico e colinérgico em ratos Diabéticos tipo 1
(Universidade Federal de Santa Maria, 2020-02-27)
Diabetes mellitus (DM) is a metabolic disorder, considered one of the biggest public health problems in the world. This disease is characterized by a state of chronic hyperglycemia that leads to metabolic disorders. Studies ...
Atividade antitumoral da berberina em células de neuroblastoma SH-SY5Y
(Universidade Federal de Santa Maria, 2017-02-23)
Neuroblastoma is the most common tumor found in the first year of life and represent 6% of the all childhood cancers. There is few options of treatment and the mortality is close to 21%, or exceeds 50% between the high ...
Associação do disseleneto de difenila e moduladores do sistema glutamatérgico frente ao dano oxidativo causado por ácido quinolínico
(Universidade Federal de Santa Maria, 2013-02-22)
Excessive formation of reactive oxygen species (ROS) and disruption of glutamate
uptake have been hypothesized as key mechanisms contributing to quinolinic acid (QA)-
induced toxicity. Thus, here we investigate if the ...
Atividade de ectoenzimas e de colinesterases e biomarcadores de estresse oxidativo em pacientes com câncer de pulmão
(Universidade Federal de Santa Maria, 2012-03-02)
Lung cancer has become one of the most commonly diagnosed neoplastic diseases, as well as one of the most lethal worldwide, characterized, therefore, as a public health problem. This spread of lung cancer in the world ...
Avaliação da capacidade do disseleneto de difenila em reduzir a falência hepática aguda induzida por paracetamol em camundongos
(Universidade Federal de Santa Maria, 2013-09-18)
Paracetamol (APAP) is commonly used analgesic and antipyretic, however high doses can induce damage hepatic. The metabolic N-acetyl-p-benzoquinone imine (NAPQI) is responsible for the toxic effects. The accumulation of ...
Investigação pós-tratamento agudo e crônico com adenosina exógena no nematoide Caenorhabditis elegans
(Universidade Federal de Santa Maria, 2021-06-25)
Adenosine is a purine, which has important biological functions for cell metabolism, in addition to many researches relating its use to neuromodulation. Caenorhabditis elegans is a non-parasitic nematode found in nature ...
Caracterização físico-química do mel do bioma pampa brasileiro e estudo do seu potencial antioxidante in vitro e in vivo em modelo de Drosophila melanogaster
(Universidade Federal de Santa Maria, 2014-03-14)
Honey is a complex mixture produced by honey bees from the nectar, which is used by
its sweetening properties, as well as by its human health benefits. The aim of this study was to
characterize, for the first time in ...