A ontologia ontocancro 3.0: representando o conhecimento dos processos inflamatórios

Abstract

In the natural process of life, people are born, grow, age and die. The degeneration of the cells that occurs in this process is unconditionally the inability to renew cell, and this failure is that live various diseases. A topic in this area is Inflammaging, which deals with the chronic inflammatory state that comes with aging. This paper developed of an ontology oriented to the study of Inflammaging unified to Ontocancro, It is proposed a mapping of existing knowledge in the genetic framework of inflamation and a comparative analysis between the tracks of the natural process of cell development with inflammation pathways inserted. To visually verify these connections used the String, a genetic link processor that provides graphs relationship between genes, showing the intensity ratio. With comparison between two pathways; detected genes of intersection between them have intensive connections to a degree of 90% reliability.