Ovário-histerectomia videoassistida ou convencional: análise álgica, inflamatória e de estresse oxidativo

Abstract

Ovariohysterectomy (OVH) is the most frequently procedure in surgical routine of small animals. Surgical approaches in dogs include standard median celiotomy or endosurgery, which provides reduced tissue trauma, such as the laparoscopic-assisted technique. The purpose of this research was to compare postoperative pain, inflammation and oxidative stress in 14 healthy dogs undergoing two-port laparoscopic-assisted OVH (GV) and conventional celiotomy approach (GC), through the use of dipyrone, scopolamine and meloxicam. A review regarding inflammation and oxidative stress in laparoscopic surgery, which constitute the first chapter of this thesis was performed. The second chapter consists on the assessment of postoperative pain using the visual analogue scale, the Melbourne University pain scale and the short-form of the Glasgow composite pain scale. The assessment were realized at two, four, six, eight, 12, 24, 36, 48 and 72 hours after surgery. No animal required rescue analgesia during at any time point. Lower and shorter pain scores were observed in the animals submitted to laparoscopic-assisted surgery. The third chapter includes inflammatory and oxidative stress assessed by white blood count (CBC) and cholinesterases (acetylcholinesterase and butyrylcholinesterase), catalase and lipid peroxidation measurement during 72 hours following surgery. The dogs submitted to conventional technic presented inflammatory white blood countain and punctual indication of lipid peroxidation, although animals operated by laparoscopic-assisted technic did not present these alterations. According to the results, we conclude that two-port laparoscopic-assisted OVH in bitches promote lower and shorter algic stimulus and lower surgical stress than OVH by median celiotomy approach, despite the anti-inflammatory use.