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Desenvolvimento e validação de método por cromatografia líquida em fase reversa para análise de febuxostate
(Universidade Federal de Santa Maria, 2013-07-25)
Febuxostat is a novel non purine drug indicated for the treatment of hyperuricemia in gout. A reversed-phase liquid chromatography (RP-LC) method was validated for the determination of febuxostat in pharmaceutical dosage ...
Aplicação de metodologia analítica para a determinação de adultarentes sintéticos em formulações fitoterápicas emagrecedoras no Brasil
(Universidade Federal de Santa Maria, 2011-03-24)
The problem of adulteration of drugs, nowadays, is not limited just to
cases of synthetic formulations (manufactured drugs). The presence of synthetic
drugs which are illegally added to herbal formulations, especially ...
Comprimidos mastigáveis de ferro carbonila para tratamento da anemia ferropriva de crianças menores de seis anos
(Universidade Federal de Santa Maria, 2006-12-20)
The objective this study is verify the efficiency and occurrence of collateral effects with the use of carbonyl iron powder, in the form of chewable tablets, in order to enable the use of an alternative to the conventional ...
Sistemas nanoestruturados contendo óleo essencial de Melaleuca alternifolia: desenvolvimento de formulações e atividade biológica
(Universidade Federal de Santa Maria, 2011-08-15)
The aim of this work was the development of nanostructured formulations containing
M. alternifolia essential oil. Polymeric nanocapsules and nanoemulsions (10 mg/mL) were
prepared by the interfacial deposition of preformed ...
Avaliação do uso de inibidores de tirosina quinase em pacientes com leucemia mielóide crônica
(Universidade Federal de Santa Maria, 2016-08-26)
Chronic myeloid leukemia (CML) results from the clonal proliferation of a hematopoietic stem cell representing approximately 15-20% of all cases of leukemia. It is characterized by the presence of the Philadelphia chromosome ...
Avaliação fitoquímica, capacidade antioxidante e fotoprotetora do extrato e formulações de Calendula officinalis L.
(Universidade Federal de Santa Maria, 2013-12-16)
There are many factors related to oxidative stress, one of which is exposure to ultraviolet
(UV) radiation, which generates reactive oxygen species (ROS). Calendula officinalis L.
presents phenolic compounds, saponins, ...
Otimização e validação da quantificação de malondialdeído plasmático por cromatografia líquida de alta eficiência com detecção visível
(Universidade Federal de Santa Maria, 2007-03-06)
The overproduction of reactive oxygen and nitrogen species or the reduction in the antioxidant capacity results in the oxidative stress. The lipid peroxidation involves the oxidative deterioration of polyunsaturated fatty ...
Avaliação da suscetibilidade de Candida glabrata resistentes ao fluconazol frente a combinações de antifúngicos
(Universidade Federal de Santa Maria, 2011-03-25)
In the last decades the invasive mycoses caused by opportunistic fungi has showed a significant growth. The extensive use of azoles showed that the development of resistance of Candida species to these drugs is an emergent ...
Desenvolvimento tecnológico de suspensões e liofilizados de nanocápsulas poliméricas para a veiculação do neuroprotetor idebenona
(Universidade Federal de Santa Maria, 2013-10-30)
Idebenone is an antioxidant, a synthetic derivative of coenzyme Q10, with several applications, such as neuroprotection. However, this drug has low solubility in water, besides is irritant substance and has chemical ...
Caracterização de antígenos imunodominantes de Pythium insidiosum reconhecidos por anticorpos de eqüinos, coelhos e bovinos
(Universidade Federal de Santa Maria, 2010-07-26)
Oomycete Pythium insisiosum is the etiologic agent of pythiosis, chronic and granulomatous disease, which affects humans and animals in tropical and subtropical areas of the world. Due to ergosterol absence in the plasmatic ...