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Desenvolvimento de formulações nanotecnológicas para o tratamento da candidíase vulvovaginal
(Universidade Federal de Santa Maria, 2012-08-21)
This work aimed the preparation of clotrimazole-loaded nanocapsule suspensions for vulvovaginal fungal infections treatment. For the first time, virgin coconut oil and medium chain triglycerides were used as an oil core ...
Avaliação da suscetibilidade de Candida spp. isoladas de candidemias: um estudo de 15 anos
(Universidade Federal de Santa Maria, 2012-04-20)
In the last two decades it has been seen a large increase in blood stream infections by
Candida spp. The candidemias are associated with high morbidity and mortality, as well as
the increase in hospital costs. The ...
Desenvolvimento e validação de metodologia analítica para avaliação de alisquireno em formulação farmacêutica
(Universidade Federal de Santa Maria, 2010-08-13)
Aliskiren is the first representative of a new class of drugs, the low molecular weight renin inhibitors, orally active and clinically used in a new effective treatment for hypertension. In the present study, the methods ...
Desenvolvimento e validação de metodologias analíticas para determinação do itraconazol matéria-prima e cápsulas
(Universidade Federal de Santa Maria, 2008-05-13)
Itraconazole is a triazole antifungical agent with a broad spectrum of activity belonging to the class of azole, indicated in the treatment of different types of mycotic infections systemic and local. Its mechanism of ...
Desenvolvimento e validação de metodologia para avaliação de fluticasona por cromatografia líquida e eletroforese capilar
(Universidade Federal de Santa Maria, 2009-03-24)
Fluticasone propionate (FP) is a synthetic glucocorticoid with potent anti-inflammatory activity that has been effectively used for the treatment of seasonal and allergic perennial rhinitis, minimizing systemic activity. ...
Desenvolvimento de nanoemulsões e nanocápsulas poliméricas contendo tioconazol e incorporação em hidrogéis
(Universidade Federal de Santa Maria, 2013-06-21)
This work aimed to develop nanoemulsions and polymeric nanocapsules containing tioconazole for the topical treatment of superficial mycoses. Initially, a method was validated by liquid chromatography with UV detection to ...
Glechon spathulata Benth.: estudo fitoquímico e biológico
(Universidade Federal de Santa Maria, 2007-07-20)
The main groups of secondary metabolites of Glechon spathulata Benth. were
evaluated by a phytochemical screening and the volatile oil obtained by
hydrodistillation was analyzed by GC-MS. Volatile oil, ethanolic crude ...
Validação de método por cromatografia líquida em fase reversa para avaliação de potência de molgramostima. Correlação com o bioensaio
(Universidade Federal de Santa Maria, 2010-09-24)
The granulocyte-macrophage colony stimulating factor (GM-CSF) is a cytokine that regulates
the proliferation and differentiation of hematopoietic progenitor cells and activates mature
granulocytes and macrophages. ...
Caracterização molecular dos rearranjos gênicos de imunoglobulinas e receptores de células T em pacientes com leucemia linfoide aguda
(Universidade Federal de Santa Maria, 2016-01-22)
Acute Lymphocitic Leukemia (ALL) is the most common cause of childhood cancer and occurs in adults in 20%. Lymphoblasts accumulation is a characteristic of the disease since the leukemic cells retain some multiplication ...
Desenvolvimento e validação de métodos para avaliação de cloridrato de fexofenadina
(Universidade Federal de Santa Maria, 2006-03-31)
The fexofenadina is an antihistamine non sedative that acts as antagonistic selective in the outlying receivers H1 of the histamine, being used in the symptomatic treatment of allergic manifestations as medication of first ...