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Desenvolvimento de nanocápsulas poliméricas contendo Indol-3-Carbinol e avaliação biológica das formulações
(Universidade Federal de Santa Maria, 2016-08-08)
Indole-3carbinol (I3C) is a phytochemical that has several therapeutic properties. However, it is unstable
against acid and light conditions. In this sense, polymeric nanocapsules are interesting alternatives for
the ...
Nanopartículas contendo propionato de clobetasol: preparação, caracterização e incorporação em hidrogéis
(Universidade Federal de Santa Maria, 2010-03-29)
The aim of this work was the development of nanostructured formulations containing
clobetasol propionate. Initially, it was validated a chromatographic method to assay clobetasol
propionate in nanocapsule suspensions. ...
Desenvolvimento de nanocápsulas para a liberação controlada de crisina: avaliação da atividade antioxidante e da citotoxicidade in vitro
(Universidade Federal de Santa Maria, 2015-09-25)
Chrysin (5,7-dihydroxyflavone) is a flavonoid (class of flavones), which presents antioxidant and antitumoral activities. However, it has low solubility and hence its bioavailability in the body is low, limiting its ...
Desenvolvimento de nanocápsulas contendo cetoprofeno e avaliação in vitro da citotoxicidade
(Universidade Federal de Santa Maria, 2013-08-28)
The aim of this work was to prepare, characterize and evaluate the in vitro cytotoxicity of Eudragit S100® nanocapsules (NC) containing ketoprofen. The nanostructured suspensions were prepared in triplicate by the method ...
Avaliação da influência do óleo e do polímero sobre as características físico-químicas e estabilidade de sistemas nanoestruturados contendo ubiquinona
(Universidade Federal de Santa Maria, 2014-03-31)
This work evaluated the influence of the composition on the physico-chemical characteristics, stability and photostability of nanostructures containing ubiquinone. Nanocapsules (NC) and nanoemulsions (NE) were prepared by ...
Tratamento de artrite com vitamina D3 livre ou nanoencapsulada: efeito sobre ectoenzimas de linfócitos em modelo animal
(Universidade Federal de Santa Maria, 2014-04-22)
Rheumatoid arthritis (RA) is a chronic, multisystem inflammatory disease characterized by symmetric and erosive synovitis. The purinergic signaling system plays an important role in the modulation of inflammatory and immune ...
Desenvolvimento de nanocápsulas poliméricas para liberação pulmonar do dipropionato de beclometasona
(Universidade Federal de Santa Maria, 2013-03-22)
Polymeric nanocapsules have been studied extensively for drug delivery by various routes of administration. Currently, the nanoencapsulation of drugs is considered the most efficient means of ensuring controlled release, ...
Desenvolvimento tecnológico de produtos secos redispersíveis a partir de nanoestruturas contendo tioconazol
(Universidade Federal de Santa Maria, 2013-04-29)
Spray-drying and freeze-drying are dehydration techniques which serve as alternative to increase the stability of formulations which are in aqueous medium. Therefore, this study objectived the development of redispersible ...
Sistemas nanoestruturados contendo óleo essencial de Melaleuca alternifolia: desenvolvimento de formulações e atividade biológica
(Universidade Federal de Santa Maria, 2011-08-15)
The aim of this work was the development of nanostructured formulations containing
M. alternifolia essential oil. Polymeric nanocapsules and nanoemulsions (10 mg/mL) were
prepared by the interfacial deposition of preformed ...
Desenvolvimento tecnológico de suspensões e liofilizados de nanocápsulas poliméricas para a veiculação do neuroprotetor idebenona
(Universidade Federal de Santa Maria, 2013-10-30)
Idebenone is an antioxidant, a synthetic derivative of coenzyme Q10, with several applications, such as neuroprotection. However, this drug has low solubility in water, besides is irritant substance and has chemical ...