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Investigação da presença e migração de metais presentes em estabilizantes e catalisadores em embalagens plásticas
(Universidade Federal de Santa Maria, 2015-03-16)
The polyvinyl chloride (PVC) and polyethylene terephthalate (PET) polymers are widely used throughout the world. Different types of compounds are used in the polymer synthesis and to improve their properties. In the case ...
Desenvolvimento de nanocápsulas para a liberação controlada de crisina: avaliação da atividade antioxidante e da citotoxicidade in vitro
(Universidade Federal de Santa Maria, 2015-09-25)
Chrysin (5,7-dihydroxyflavone) is a flavonoid (class of flavones), which presents antioxidant and antitumoral activities. However, it has low solubility and hence its bioavailability in the body is low, limiting its ...
Desenvolvimento e validação de método por cromatografia líquida em fase reversa para análise de rivaroxabana
(Universidade Federal de Santa Maria, 2015-02-27)
Rivaroxaban is an oral anticoagulant drug indicated for deep venous thromboembolism prophylaxis. A reversed-phase liquid chromatography (RP-LC) method was developed and validated for the determination of rivaroxaban in ...
Ebastina: obtenção de novas formas cristalinas e caracterização no estado sólido
(Universidade Federal de Santa Maria, 2015-12-04)
Ebastine (EBA) is a second-generation antihistamine with poor water solubility. It is used in the treatment of allergic rhinitis and chronic idiopathic urticaria. For oral administration of drugs, there is a preference for ...
Desenvolvimento de hidrogéis mucoadesivos contendo nanocápsulas catiônicas de clotrimazol para o tratamento da candidíase vulvovaginal
(Universidade Federal de Santa Maria, 2015-03-16)
This study aimed the development of a novel formulation for the treatment of vulvovaginal candidiasis. Polymeric nanocapsules of Eudragit® RS100 were used as a clotrimazole carrier system and evaluated for their mucoadhesive ...
Suscetibilidade de trichophyton rubrum e trichophyton mentagrophytes frente a agentes antifúngicos
(Universidade Federal de Santa Maria, 2015-05-29)
Dermatophytes are a group of fungi with the capacity to invade keratinized tissues and cause infections called dermatophytosis. They are common worldwide, and does not know the true incidence because it is not notifiable. ...
Estudo de toxicidade aguda e subaguda do extrato bruto das cascas de Luehea divaricata Mart. em ratos wistar
(Universidade Federal de Santa Maria, 2015-12-14)
The species Luehea divaricata Martius belongs to the Malvaceae family and is popularly known as "açoita-cavalo." It occurs naturally in northeastern Argentina, eastern Paraguay and northern Uruguay. In Brazil, predominates ...
Nanopartículas de quitosana pH-sensíveis contendo doxorrubicina: desenvolvimento e estudo da atividade antitumoral in vitro
(Universidade Federal de Santa Maria, 2015-09-01)
Cancer is a highly complex disease and the most common treatments are limited to chemotherapy, radiation and surgery. However, the occurrence of side effects is frequent, especially due to limited drug capability to act ...
Uso de um escore derivado do hemograma na predição de risco de pacientes submetidos à cirurgia cardíaca com circulação extracorpórea
(Universidade Federal de Santa Maria, 2015-04-29)
Some CBC parameters have been implicated in individual susceptibility to
death, both in heart disease and cardiac surgery populations. The cellular elements
of blood are widely affected during cardiopulmonary bypass ...
Desenvolvimento tecnológico de nanocápsulas para a liberação controlada do neuroprotetor vimpocetina
(Universidade Federal de Santa Maria, 2015-05-27)
The Vinpocetine is a synthetic derivative of the vincamine alkaloid, which has a significant neuroprotective effect and is used in the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's, as well ...