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Envolvimento do canal TRPA1 nos comportamentos do tipo depressivo e ansioso em um modelo de esclerose múltipla progressiva em camundongos
(Universidade Federal de Santa Maria, 2020-09-25)
Background and Purpose: Progressive multiple sclerosis (PMS) is a neurological disease associated with the development of depression and anxiety, and treatments available are unsatisfactory. The transient potential receptor ...
Efeito modulatório in vitro da quetiapina não-metabolizada na citotoxicidade e ativação inflamatória de células brancas e na formação de armadilhas extracelulares de neutrófilos
(Universidade Federal de Santa Maria, 2020-02-19)
Quetiapine (QUE) is a highly complex drug that, due to its different forms of interaction with receptors, has great clinical applicability. Although widely used, QUE brings with it a range of side effects that include, in ...
Beta-cariofileno atenua dano cognitivo induzido pela exposição ao aspartame em ratos pela modulação da atividade da acetilcolinesterase e da Via BDNF/TrKB
(Universidade Federal de Santa Maria, 2021-08-26)
Aspartame (ASP) is a widely used as a tabletop sweetener and sucrose substitute in many
food matrices. However, several studies have reported that exposure to ASP can damage
biological tissues, such as the central nervous ...
Efeitos benéficos do ácido rosmarínico em modelos de atividade epileptiforme in vivo e in vitro induzidos por pilocarpina
(Universidade Federal de Santa Maria, 2021-12-17)
Epilepsy is a chronic neurological condition marked by the occurrence of epileptic seizures that cause enormous damage to the quality of life of affected patients. Thus, understanding the molecular bases responsible for ...
Efeito do treinamento hipóxico intermitente sobre o ganho de peso, consumo calórico e perfil bioquímico em ratos submetidos à diferentes dietas
(Universidade Federal de Santa Maria, 2011-07-21)
This work investigated the effect of intermittent hypoxic training (IHT) sessions
under bodyweight, food intake and biochemical parameters in Wistar rats fed normo
fat (NF) and high fat (HF) diets. Forty rats were divided ...
Efeito da anandamida nos movimentos de mascar no vazio induzidos por haloperidol em ratos: participação do receptor CB1
(Universidade Federal de Santa Maria, 2012-09-05)
Treatment with antipsychotic drugs may cause tardive dyskinesia in humans and orofacial dyskinesia in rodents. Although the dopaminergic system in basal ganglia has been implicated in these movement disorders, their ...
Efeitos de resíduos de psicofármacos na água sobre o desenvolvimento inicial de zebrafish
(Universidade Federal de Santa Maria, 2015-07-01)
The growing and continuous use of drugs by the human population transformed the
pharmacological agents in "emerging pollutants" are often found in aquatic
environments. The consequences of this finding are still unclear, ...
Efeitos do organofosforado parationato metílico sobre o eixo hipotálamo-hipófise-interrenal em peixe-zebra (Danio rerio)
(Universidade Federal de Santa Maria, 2013-04-18)
Organophosphorus compounds such as methyl-parathion are used in the various stages of production to control pests both in agricultural activity as in aquaculture. The mechanism of action of this type of compound is the ...
Efeitos do AMPc intracelular sobre a diferenciação de células progenitoras neurais
(Universidade Federal de Santa Maria, 2022-02-25)
Intermediate and extrinsic intrinsic stimuli contribute to the growth of progenitor cells (NPCs).
Extracellular stimuli cause NPCs to differentiate into glial cells and neurons. At the intracellular
level, as signaling ...
Atividade anestésica em robalos-peva (Centropomus parallelus) e caracterização química do óleo essencial das folhas de nectandra megapotamica (Spreng.) Mez (Lauraceae)
(Universidade Federal de Santa Maria, 2011-12-14)
The increasing expansion of aquaculture, the stress on the animals in farming systems and the adverse effects caused by conventional anesthetics has encouraged the search for natural anesthetics, safer, more effective, ...