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Aumento da suscetibilidade ao pentilenotetrazol após a sobrevivência de um quadro de malária cerebral em camundongos
(Universidade Federal de Santa Maria, 2017-07-10)
Malaria is considered a neglected disease and public health problem, affecting more than 200 million people worldwide. Plasmodium falciparum, one of the four human parasitic species, is responsible for the development of ...
Efeito do ácido rosmarínico sobre as crises epilépticas e alterações comportamentais em diferentes modelos experimentais de epilepsia
(Universidade Federal de Santa Maria, 2016-03-01)
Epilepsy is a chronic neurological disease characterized by recurrent seizures. Current anticonvulsant
drugs are ineffective in nearly one third of patients and may cause significant adverse effects.
Rosmarinic acid is ...
Avaliação do papel do receptor para tromboxanos (TP) durante a epileptogênese
(Universidade Federal de Santa Maria, 2020-03-05)
Convulsive status epilepticus (SE) is a medical emergency that can lead to epilepsy, long lasting brain damage and death. It is known that there is a strong link between epilepsy and inflammation. For instance, it has been ...
Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsia
(Universidade Federal de Santa Maria, 2015-08-31)
The epilepsy is a neurological disorder manifested by recurrent unprovoked
seizures, resulting in harmful effects on the patients. Epileptic seizures are generated
from hypersincronic abnormal discharges of neurons, ...
Efeitos benéficos do ácido rosmarínico em modelos de atividade epileptiforme in vivo e in vitro induzidos por pilocarpina
(Universidade Federal de Santa Maria, 2021-12-17)
Epilepsy is a chronic neurological condition marked by the occurrence of epileptic seizures that cause enormous damage to the quality of life of affected patients. Thus, understanding the molecular bases responsible for ...
Atividade e estado de fosforilação da Na+,K+-ATPase nas convulsões induzidas por pentilenotetrazol em camundongos
(Universidade Federal de Santa Maria, 2012-02-29)
In the brain, Na+,K+-ATPase activity is essential for maintaining of the electrochemical gradient
underlying the resting potential and release and uptake of neurotransmitters, and a decrease in its
activity alters brain ...
Associação entre β-cariofileno e pregabalina apresenta ação anticonvulsivante aguda em modelo de crises epilépticas induzidas por pentilenotetrazol em ratos
(Universidade Federal de Santa Maria, 2021-07-23)
Epilepsy is a chronic neurological disease characterized by recurrent seizures. However, current anticonvulsants are ineffective in nearly a third of patients and can cause adverse effects. Beta-caryophyllene is agonist ...
Hormônio alfa estimulante dos melanócitos (α-MSH) não modifica as convulsões induzidas por pentilenotetrazol e por pilocarpina em camundongos
(Universidade Federal de Santa Maria, 2013-11-26)
Alpha-melanocyte stimulating hormone (α-MSH) is a pro-opiomelanocortin (POMC)-derived peptide involved in different neurological functions that also exerts anti-inflammatory effects, including in the central nervous system ...