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Ação protetora da Carya illinoensis sobre a toxicidade induzida por ciclofosfamida em ratos
(Universidade Federal de Santa Maria, 2010-01-29)
Cyclophosphamide (CP) is an alkylating agent widely used in anticancer and immunosuppression therapy. Like other chemotherapies, this drug can induce damage in healthy tissues, generating multiple organ toxicity. The study ...
Adição do óleo essencial de Lippia alba (Mill) N. E. Brown na dieta do jundiá: análise do crescimento e da resposta antioxidante
(Universidade Federal de Santa Maria, 2013-02-06)
Fish become more susceptible to stress and, consequently, to the onset of disease with the intensification of rearing. In an attempt to minimize this problem, farmers use agrochemicals that, besides harming the environment, ...
Influência da hipóxia sobre parâmetros de estresse oxidativo e viabilidade mitocondrial de jundiás expostos ao manganês
(Universidade Federal de Santa Maria, 2012-02-01)
Metals environment aquatic contamination has been a growing problem with serious consequences to life of different species over time, even after interrupted their emission into the environment. Among relevance metals, ...
Efeitos benéficos do extrato das cascas de noz pecã (Carya illinoensis) sobre parâmetros bioquímicos e comportamentais de camundongos expostos ao fumo passivo
(Universidade Federal de Santa Maria, 2011-01-28)
Smoking is the second major reason of death worldwide, amounting 5 millions
of deaths annually. The adverse effects of cigarette smoking are not limited to active
smokers, but also to passive smokers, which comprise one ...
Influência do exercício físico sobre parâmetros de comportamento e estresse oxidativo em modelo animal de discinesia tardia
(Universidade Federal de Santa Maria, 2008-03-07)
Regular practice of physical activity promotes beneficial effects to the body. However, excessive duration and intensity of exercise may surpass individual tolerance to
exercise, generating oxidative stress (OS). Studies ...
Estudo toxicológico comparativo referente ao haloperidol na sua forma livre e nanoencapsulada
(Universidade Federal de Santa Maria, 2015-08-14)
The association of haloperidol (HP) with polymeric nanocapsules causes a significant improve in therapeutic efficacy prolongs the drug time of action and reduces motor side effects in rats. However, in view of the HP ...
Quantificação de α-tocoferol, retinol e carotenóides e seus possíveis efeitos sobre a peroxidação lipídica em trabalhadores expostos a solventes
(Universidade Federal de Santa Maria, 2011-02-18)
Oxidative stress is a process characterized by the antioxidant defense system
decrease and/or an excessive reactive species (RS) production. RS are substances
capable of attacking proteins, lipids and DNA. The oxidative ...
Influência farmacogenética da enzima SOD2 na resposta in vitro ao resveratrol de células mononucleares
(Universidade Federal de Santa Maria, 2014-10-03)
Resveratrol (RES) is an anti-aging molecule that provides both anti-inflammatory and antioxidant properties. However, it is unclear whether the basal oxidative state of the cell has any influence on the effects of this ...
Influência do polimorfismo Ala16Val do gene da enzima superóxido dismutase (SOD2) no efeito antioxidante in vitro do citrato de clomifeno
(Universidade Federal de Santa Maria, 2011-08-16)
To investigate the in vitro antioxidant properties of the ovulation induction drug,
Citrate clomiphene (CC), and to access whether its effects are influenced by the
Ala16Val polymorphism in the SOD2 gene, which encodes ...
Frutose-1,6-bisfosfato e N-acetilcisteína atenuam a formação de produtos proteicos de oxidação avançada, uma nova classe de mediadores inflamatórios, in vitro
(Universidade Federal de Santa Maria, 2012-09-19)
The assessment of biomarkers of reactions involving reactive oxygen species have the
potential not only to determine the extent of oxidative damage, but also to predict the
effectiveness of therapeutic strategies aimed ...