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Selegilina reverte a piora da memória inuzida por Aβ25-35 em camundongos: envolvimento da atividade da MAO-B
(Universidade Federal de Santa Maria, 2013-02-28)
Alzheimer s disease (AD) is biochemically characterized by the occurrence of extracellular deposits of amyloid beta peptide (Aβ) and intracellular deposits of the hyperphosphorylated tau protein, which are causally related ...
Susceptibilidade in vitro de isolados de Pythium insidiosum frente a aminoglicosídeos e tigeciclina
(Universidade Federal de Santa Maria, 2012-03-15)
Pythiosis is a chronic disease that affects humans, other mammals and birds. It is caused by the
aquatic oomycete Pythium insidiosum. Pythiosis progresses rapidly and can become life
threatening if not treated in the ...
Influência de diferentes ácidos graxos sobre parâmetros comportamentais e oxidativos em ratos submetidos ao estresse agudo
(Universidade Federal de Santa Maria, 2013-08-30)
The fatty acids (FA) are important constituents of brain phospholipid membranes and play important roles in the central nervous system (CNS) may modify the plasticity and fluidity, and act decisively in the development of ...
Envolvimento do receptor de potencial transitório A1 (TRPA1) em um modelo de dor neuropática mantida pelo simpático em camundongos
(Universidade Federal de Santa Maria, 2012-05-26)
Some forms of neuropathic pain are maintained by sympathetic fibers, but the underlying mechanisms are poorly understood. Thus, the aim of this study was to investigate the possible involvement of the TRPA1 receptor as ...
Hormônio alfa estimulante dos melanócitos (α-MSH) não modifica as convulsões induzidas por pentilenotetrazol e por pilocarpina em camundongos
(Universidade Federal de Santa Maria, 2013-11-26)
Alpha-melanocyte stimulating hormone (α-MSH) is a pro-opiomelanocortin (POMC)-derived peptide involved in different neurological functions that also exerts anti-inflammatory effects, including in the central nervous system ...
Envolvimento das poliaminas no ataque agudo de gota em camundongos
(Universidade Federal de Santa Maria, 2016-02-26)
Gout attack is characterized severe joint pain and inflammation with concomitant accumulation of monosodium urate (MSU) crystals. However, gout and the mechanisms responsible for the acute attacks are poorly understood, ...