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Itens para a visualização no momento 101-110 of 153
Efeito neuroprotetor da Berberina na neurotoxicidade induzida por estreptozotocina e lipolissacarídeo em ratos
(Universidade Federal de Santa Maria, 2019-10-29)
Alzheimer's disease (AD) is considered the major cause of dementia and is characterized by changes in the cholinergic and purinergic system, oxidative stress, inflammatory process and metabolic changes that, in turn, are ...
Silimarina modifica a atividade da Na+/K+-ATPase e da MAO e modula a ação de antimicrobianos in vitro
(Universidade Federal de Santa Maria, 2015-06-10)
The Silymarin is a flavonolignan complex isolated from milk thistle seeds of Silybum marianum being used in the treatment of injury related to oxidative stress, including liver and neurological diseases, as Parkinson ...
Síntese e atividades antioxidante e antitumoral de 5´-arilseleno azidotimidina
(Universidade Federal de Santa Maria, 2012-03-30)
The synthesis of compounds that use a nucleoside as the base structure, has an intense field application. Among these compounds, the most known nowadays is azydothymidine or zidovudine, a drug which was first synthesized ...
Estudos teóricos e de modelagem molecular in silico aplicados à interação entre a enzima delta-aminolevulinato desidratase e disselenetos de diarila
(Universidade Federal de Santa Maria, 2013-05-06)
Delta-aminolevulinic acid dehydratase (δ-ALA-D) is an essential metalloprotein found in several biological processes, since it is able to catalyze the formation of porphobilinogen (PBG), a precursor monopyrol of tetrapyrroles ...
Efeitos de compostos orgânicos de selênio frente à toxicidade induzida por glutamato e metilmercúrio
(Universidade Federal de Santa Maria, 2012-03-02)
Organoselenium compounds have been proposed as potential pharmacological agents in the treatment of diseases associated with the oxidative stress. Particularly, ebselen and diphenyl diselenide has been demonstrated as ...
Efeitos da N-acetilcisteína sobre a toxicidade do ditelureto de difenila no encéfalo de camundongos
(Universidade Federal de Santa Maria, 2015-11-18)
The diphenyl ditelluride (PhTe)2 is one of the most toxic organic compounds of tellurium which can make their use unsafe. The mechanism(s) involved in (PhTe)2 toxicity is(are) elusive, but thiol oxidation of critical ...
Estudo do perfil oxidativo e avaliação de parâmetros enzimáticos em pacientes com câncer de próstata
(Universidade Federal de Santa Maria, 2012-12-19)
Prostate cancer is recognized as one of the most important medical problems in
the male population. Inherent or acquired alterations in cellular metabolism that occur
over the years may be involved in the process of ...
Estudo etnobotânico, microbiológico e perfil toxicológico in vitro e in vivo de Rhaphiodon echinus (Nees & Mart) Schauer
(Universidade Federal de Santa Maria, 2016-01-22)
Medicinal plants have long been used in traditional medicine for the treatment of various diseases, especially because they have low cost and lower toxicity compared to synthetic drugs. The pharmaco-toxicological interest ...
Efeitos de compostos orgânicos de selênio na toxicidade induzida por metilmercúrio: estudos in vitro
(Universidade Federal de Santa Maria, 2014-10-23)
Methylmercury (MeHg) is a known environmental pollutant that affects a variety of cellular functions, and the
oxidative stress is one of the proposed mechanisms to explain its toxicity. Inhibition of selenoenzymes
(Glutathione ...
O efeito protetor do exercício físico e da suplementação com cafeína nas convulsões e dano oxidativo induzido por pentilenotetrazol em ratos
(Universidade Federal de Santa Maria, 2012-10-05)
Seizures are the main clinical manifestation of epilepsy. Epilepsy is a common neurological disorder with an incidence of 1% in the general population, with about 20 to 30% of patients are refractory to treatment with ...