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Itens para a visualização no momento 61-70 of 153
Interferências do manganês no metabolismo de lipídeos e na reprodução do nematódeo Caenorhabditis elegans
(Universidade Federal de Santa Maria, 2016-05-24)
The transition metal manganese (Mn) has many physiological properties such as its role as enzyme cofactor. However, excessive environmental exposure to this metal has represented a pre-factor to the occurrence of a ...
Disseleneto de difenila em modelos de infecção viral causada por herpes simplex vírus dos tipos 1 e 2
(Universidade Federal de Santa Maria, 2017-03-02)
Infectious diseases caused by herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are among the pathologies that most affect the population. The search for new therapeutic alternatives for its treatment becomes relevant ...
Propriedades antinociceptivas e antioxidantes do disseleneto de bis(fenilimidazoselenazolila) em roedores
(Universidade Federal de Santa Maria, 2016-11-07)
The current available drugs for treatment of disorders related to pain and inflammation present several adverse effects, then the investigation for novel molecules are required. It is known that organoselenium compounds ...
Infusão intra-hipocampal de espermidina melhora a persistência da memória e a persistência da reconsolidação da memória em ratos
(Universidade Federal de Santa Maria, 2016-08-19)
The persistence of memory requires a delayed healing process (12-24 h after the acquisition) wherein the synthesis of new proteins and derived neurotrophic factor (BDNF), are essential. The polyamines putrescine, spermidine ...
Efeito do haloperidol ou risperidona sobre parâmetros comportamentais, inflamatórios e dopaminérgicos em cérebro de ratos
(Universidade Federal de Santa Maria, 2016-08-29)
Schizophrenia is a psychiatric disorder that affects about 1% population around the world and its pharmacological
treatment consist in the use of antipsychotics. Haloperidol, a first generation antipsychotic (FGA) acts ...
Ação neuroprotetora e anti-inflamatória do disseleneto de difenila e exercício de natação em modelo de envelhecimento em ratos
(Universidade Federal de Santa Maria, 2016-01-29)
Aging is a degenerative process that affects virtually all living organisms. The increase in the inflammatory process seems to be one of the main factors that contribute to aging and inflammaging and neuroinflammation in ...
Caenorhabditis elegans como modelo experimental para estudos toxicológicos e farmacológicos dos extratos de Luehea divaricata e Paullinia cupana
(Universidade Federal de Santa Maria, 2016-03-16)
The nematode Caenorhabditis elegans is a valuable tool for toxicological and
pharmacological studies. Despite its simple body, the most part of its genes and signaling
pathways are similar to humans, and alterations in ...
Propriedades de proteção gastrointestinal da Rosmarinus officinalis l. em associação a testes microbiológicos e antioxidantes in vitro e ex vivo
(Universidade Federal de Santa Maria, 2016-03-18)
The elevate production of reactive species over physiological levels and associated to pathogenic bacteria could
represent a high risk for many diseases. The high levels of oxidative stress and inflammation can be present ...
Envolvimento dos sistemas purinérgico, colinérgico e estresse oxidativo nos distúrbios da tireoide: possível efeito protetor da quercetina
(Universidade Federal de Santa Maria, 2017-02-22)
Thyroid hormones modulate the metabolic pathways in the body and have important physiological
functions in the brain and vascular system. Changes in their production or distribution lead to disorders
such as hypothyroidism ...
Efeitos da suplementação com disseleneto de difenila e do exercício físico de natação na memória de ratos wistar velhos
(Universidade Federal de Santa Maria, 2017-03-03)
Aging occurs at all cellular levels of the body, being defined as a degenerative, progressive
and irreversible process. An important feature of the aging process is the gradual loss of
memory. Given the scarcity of ...