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Envolvimento dos sistemas purinérgico, colinérgico e estresse oxidativo nos distúrbios da tireoide: possível efeito protetor da quercetina
(Universidade Federal de Santa Maria, 2017-02-22)
Thyroid hormones modulate the metabolic pathways in the body and have important physiological
functions in the brain and vascular system. Changes in their production or distribution lead to disorders
such as hypothyroidism ...
Efeitos da suplementação com disseleneto de difenila e do exercício físico de natação na memória de ratos wistar velhos
(Universidade Federal de Santa Maria, 2017-03-03)
Aging occurs at all cellular levels of the body, being defined as a degenerative, progressive
and irreversible process. An important feature of the aging process is the gradual loss of
memory. Given the scarcity of ...
Ação farmacológica do 4,4’-dicloro-difenil disseleneto em modelos de hiperglicemia e obesidade em ratos
(Universidade Federal de Santa Maria, 2017-03-03)
The obesity epidemic is a worldwide public health problem and is considered one of the leading causes of death and disability worldwide. This is because the pathophysiology of this disease is extremely complex and involves ...
Desenvolvimento de nanocápsulas contendo disseleneto de bis (p-metoxifenila): biodistribuição e efeitos em modelos de dor em camundongos
(Universidade Federal de Santa Maria, 2017-08-11)
The chronic pain is a global public health problem and its pharmacological management is still unsatisfactory. The identification of novel molecules to effectively treat chronic pain states remains a major objective in ...
Efeito do guaraná (Paullinia cupana) em parâmetros comportamentais e sistemas purinérgico e colinérgico em modelo de hiperlipidemia
(Universidade Federal de Santa Maria, 2017-08-28)
Hyperlipidemia is a condition associated with cognitive and inflammatory
disorders, with has a high impact on cardiovascular diseases and central nervous
system. Guarana, on the other hand, presents potent anti-inflammatory ...
Efeito preventivo do flavonoide quercetina nos sistemas purinérgico e colinérgico de modelo experimental de hiperlipidemia
(Universidade Federal de Santa Maria, 2017-08-30)
Hyperlipidemia (HL) is characterized by changes in lipid metabolism, being one of the main metabolic disorders. HL is recognized as a risk factor for the development of atherosclerosis, characterized by the presence of ...
Estudo comparativo de β-selenoaminas e disselenetos em modelos hepatotóxico e alternativo
(Universidade Federal de Santa Maria, 2017-08-17)
Organic selenium compounds, Ebselen and diphenyl diselenide (DPDS), possess numerous characteristics such as, antioxidant activity, anti-inflammatory among others. In this regard, new molecules have been produced through ...
Efeitos da cafeína e do diclofenaco sobre o estresse oxidativo e a inflamação em ratos submetidos ao exercício físico
(Universidade Federal de Santa Maria, 2015-07-01)
Exercise can represent a physical stress that disrupts the homeostasis. Elevated muscle oxygen consumption increases reactive oxygen species (ROS) and inflammatory proteins production, leading to oxidative stress and ...
Polimorfismo Ala16ValMnSOD na epilepsia: envolvimento dos marcadores inflamatórios, oxidativos e glicolipídicos
(Universidade Federal de Santa Maria, 2019-08-17)
Epilepsy is a neurological disease that affects around 1% of world population, with neurobiological, neurochemical, cognitive and psychological consequences. Despite of the good prognosis, there is a high proportion of ...
O papel do polimorfismo Ala16Val da Mn-SOD no acidente vascular encefálico crônico: um estudo clínico
(Universidade Federal de Santa Maria, 2019-08-17)
Considered one of the most common neurological diseases, stroke has a high morbidity and mortality, and corresponds to 85% of disease cases. Several factors are involved in disease etiology, such as changes in vascular ...