Buscar
Itens para a visualização no momento 1-10 of 12
Mecanismos envolvidos nos efeitos do seleneto vinílico bis substituído (svbs) em modelos animais de depressão e de dor
(Universidade Federal de Santa Maria, 2011-03-18)
The association between depression and chronic pain is frequent and bidirectional. The high number of patients with depression and chronic pain who are refractory to currently available drugs makes it important search for ...
A influência do processo inflamatório nas convulsões e no déficit cognitivo induzidos pelo ácido glutárico em ratos jovens
(Universidade Federal de Santa Maria, 2011-02-04)
Glutaric acidemia type I (GA-I) is an inborn error of metabolism (EIM), characterized biochemically by major accumulation of glutaric acid (GA) and pathologically by a characteristic striatal degeneration. The clinical ...
Avaliação toxicológica de compostos orgânicos de telúrio sobre o desenvolvimento pré-natal em camundongos
(Universidade Federal de Santa Maria, 2011-03-25)
It is known that most chemical agents readily cross the placenta and thus may be considered that maternal exposure to external agents can result in toxic effects on embryo-fetal organism. Considering the chemical characteristics ...
Investigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinais
(Universidade Federal de Santa Maria, 2011-03-18)
Oxidative stress (OS) is involved in the development of several disorders involving the central nervous system, such as Alzheimer s disease (AD). Considering the limitations of current therapeutics for AD, there is still ...
Envolvimento do sistema da tiorredoxina nas alterações induzidas pelo chumbo in vitro e in vivo: implicações na toxicidade do chumbo
(Universidade Federal de Santa Maria, 2011-11-30)
Oxidative stress is an important molecular mechanism of lead (Pb) toxicity. The thioredoxin
system (selenoenzyme thioredoxin reductase-TrxR, thioredoxin protein- Trx and NADPH) is essential
for the antioxidant defense ...
Avaliação do disseleneto de difenila e análogos como substratos da tioredoxina redutase
(Universidade Federal de Santa Maria, 2011-07-15)
Since the successful use of the organoselenium compound ebselen in clinical trials for the treatment of neuropathological conditions associated with oxidative stress, there have been concerted efforts geared towards ...
A melhora da memória induzida por espermidina envolve a fosforilação da pkc, pka e creb em hipocampo de ratos
(Universidade Federal de Santa Maria, 2011-09-08)
The endogenous poliaminas, putrescine, spermidina and spermine are aliphatics amines that are present in high concentrations in the central nervous system (SNC). The action of the poliamines involves the modulation of ...
Parâmetros toxicológicos em carpas (Cyprinus carpio) expostos a uma formulação comercial de clomazone (gamit®)
(Universidade Federal de Santa Maria, 2011-10-07)
Commercial formulations of the herbicide clomazone have been widely used in
agriculture and fish farming to control weeds. Fish can be affected when the water
reaches the drainage waterways, causing an imbalance in the ...
Interações entre o estresse repetido e clomipramina: diferentes respostas em ratos machos e fêmeas
(Universidade Federal de Santa Maria, 2011-10-14)
Repeated stress or stressful events has been reported to induce anxiety and depression. Differential
responses to repeated stress and antidepressant treatments have been observed in males and females.
Clomipramine is a ...
Efeitos do cloreto de mercúrio e do cloreto de zinco sobre parâmetros renais e hepáticos em ratas lactantes e não-lactantes
(Universidade Federal de Santa Maria, 2011-04-08)
The aim of this study was to compare the effects of mercuric chloride (HgCl2)
on renal and hepatic parameters in adult non-lactating and lactating rats and their pups
and to assess the potential preventive role of Zn, ...