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Reposicionamento de medicamentos em oncologia e doenças infecciosas: avaliação da atividade biológica de dissulfiram e ebselen
(Universidade Federal de Santa Maria, 2022-02-18)
Efforts are currently being invested in discovering more effective, selective and innovative antineoplastic and antimicrobial therapies. An alternative, faster process may arise through repositioning, also called drug ...
Perfil sorológico e oxidativo de gestantes recebendo tratamento para infecção pelo Toxoplasma gondii e acompanhamento dos resultados perinatais
(Universidade Federal de Santa Maria, 2022-03-25)
Toxoplasmosis is a worldwide pathology, caused by the protozoan Toxoplasma gondii (T. gondii), which can affect humans at any period of life, however, it becomes extremely relevant when it affects women for the first time ...
Estudos de métodos cromatográficos e biológico para análise do anticorpo monoclonal ramucirumabe
(Universidade Federal de Santa Maria, 2022-01-28)
Ramucirumab (RAM) is a human anti–VEGFR–2 monoclonal antibody that develops its anti–angiogenic function by decreasing vascularization to reduce tumor growth. . It is clinically used for the treatment of adult patients ...
Filmes de polissacarídeos naturais para a veiculação cutânea de nanocápsulas de silibinina no tratamento da dermatite atópica
(Universidade Federal de Santa Maria, 2022-08-29)
Current treatments for atopic dermatitis have restrictions adverse effects, and there is a need to develop therape due to the limited efficacy and pronounced utic alternatives. Thus, this study aimed to associate the ...
Formulações farmacêuticas contendo nanocápsulas poliméricas de óleo de romã e 3,3’-diindolmetano com potencial aplicação na terapia do melanoma cutâneo
(Universidade Federal de Santa Maria, 2022-08-12)
Cutaneous melanoma is a skin cancer originated in the melanocytes and is considered the biggest cause of deaths considering all cutaneous neoplasms. Because of its aggressiveness, researching for new therapies applying ...
Reposicionamento de medicamentos em doenças infecciosas e avaliação da atividade biológica de inibidores da bomba de prótons e benzodiazepínicos
(Universidade Federal de Santa Maria, 2022-09-22)
A pathological condition with a high level of severity, caused by drug resistance, is one of the major public health
problems worldwide and has worrying consequences. This scenario becomes more complex when we mention ...
Estudo de bioensaios e métodos cromatográficos para avaliação de potência/teor de toxina botulínica tipo A
(Universidade Federal de Santa Maria, 2022-07-19)
Botulinum neurotoxin type A (BoNTA) belongs to a family of toxins which are produced by Clostridium botulinum. Their clinical use was approved in 1989 and since then, was used for therapeutic and aesthetic purposes. In the ...
Reposicionamento dos antidepressivos fluoxetina e paroxetina
(Universidade Federal de Santa Maria, 2022-08-23)
The substantial increase in multidrug resistant (MDR) bacteria makes efforts to find more effective antimicrobial therapies urgent. Drug repositioning, defined as the process of investigating new uses for drugs that have ...
Pesquisa de métodos cromatográficos para quantificação e caracterização do certolizumabe pegol
(Universidade Federal de Santa Maria, 2022-05-24)
Certolizumab pegol (CZP) is a fragment of a recombinant humanized monoclonal
antibody (mAb) produced in E. coli, conjugated with polyethylene glycol (PEG) that
acts by inhibiting the activity of Tumor Necrosis Factor ...
Atividade antimicrobiana e antibiofilme de porfirinas catiônicas meso-tetra (piridil) contendo cisplatina
(Universidade Federal de Santa Maria, 2022-09-29)
Biofilms are responsible for up to 80% of antimicrobial-resistant nosocomial infections. Most of these infections are associated with the use of medical devices such as urinary catheters, and in this context, it is estimated ...