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Nanocapsules of the tucumã oil (Astrocaryum vulgare Mart): preparation, characterization, safety evaluation in vitro and in vivo and antitumoral effectiveness in vitro
(Universidade Federal de Santa Maria, 2019-08-23)
Breast cancer is a disease of great molecular complexity and its incidence grows every year.
By 2019 approximately sixty thousand new cases are expected in Brazil, as it generates
concern mainly for women. In view of ...
Estudo longitudinal do perfil oxidativo em gestantes saudáveis e com complicações gestacionais
(Universidade Federal de Santa Maria, 2019-09-27)
During gestation, even though it is a physiological process, there is oxidative stress due to a
greater metabolic demand and an increase in tissue oxygen consumption, especially in the
placenta, in response to fetal ...
Staphylococcus coagulase negativos isolados de hemoculturas de recém-nascidos e efeito antibacteriano sinérgico in vitro de estatinas com um composto triazeno
(Universidade Federal de Santa Maria, 2019-08-16)
Bloodstream infections (BSI) are among the most frequent and serious infectious complications related to
neonatal infections, responsible for high morbidity and mortality rates. Coagulase-negative staphylococci
(CoNS) ...
Chenopodium ambrosioides L. do uso popular aos ensaios pré-clínicos: análise química, potencial anti-inflamatório e estudo da toxicidade
(Universidade Federal de Santa Maria, 2019-08-19)
Chenopodium ambrosioides L., popularly known as Erva-de-Santa-Maria, is widely used in folk medicine against many diseases, as anti-inflammatory, healing, among others. In 2009, it was inserted in RENISUS, due to its wide ...
Desenvolvimento de formas farmacêuticas sólidas e semissólidas contendo piperina associada a nanocarreadores
(Universidade Federal de Santa Maria, 2018-08-17)
The possibility of associating natural actives with nanostructured systems appears as a less invasive
treatment option for the organism. This is because, nanoparticles are able to control the release and
attenuate the ...
Ruellia angustiflora (Nees) Lindau Ex Rambo (Acanthaceae): estudo químico e biológico
(Universidade Federal de Santa Maria, 2020-03-27)
Ruellia angustiflora (Nees) Lindau Ex Rambo (Acanthaceae) is popularly known as “fire flower” and its leaves are used to promote wound healing, but there is no scientific evidence to support its popular use. This thesis ...
Hesperozygis ringens (Benth). Epling: caracterização química e atividade biológica
(Universidade Federal de Santa Maria, 2020-03-26)
Hesperozygis ringens (Benth.) Epling (Lamiaceae), is an aromatic plant, endemic to southern
Brazil, it is popularly used as an insecticide, but it is not properly studied in the literature. In
view of this gap, the ...
Desenvolvimento e estudo da atividade antitumoral in vitro de nanopartículas poliméricas pH-sensíveis conjugadas com transferrina para liberação vetorizada de doxorrubicina
(Universidade Federal de Santa Maria, 2020-08-31)
Doxorubicin (DOX) is an anthracycline antibiotic widely used in cancer therapy, being
effective against a number of tumors. However, its use may promote the development of
multidrug resistance on tumor cells beside other ...
Aspergillus spp.: suscetibilidade aos antifúngicos isolados e em associação por diferentes metodologias e detecção de mecanismos de resistência a azólicos
(Universidade Federal de Santa Maria, 2018-01-19)
Aspergillosis is a group of diseases among the main causes of morbidity and mortality in immunosuppressed patients. Aspergillus fumigatus is the most common species that causes invasive and non-invasive aspergillosis in ...
Suscetibilidade in vitro e in vivo de Pythium insidiosum frente a antibacterianos (macrolídeos, oxazolidinonas e pleuromutilinas) e miltefosina
(Universidade Federal de Santa Maria, 2018-08-20)
Pythiosis is an infection caused by the oomycete Pythium insidiosum that affects humans and other wild and domestic mammals, presenting difficulties in both diagnosis and treatment. Pythiosis cases do not respond satisfactorily ...