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Itens para a visualização no momento 11-20 of 36
Associação do disseleneto de difenila e moduladores do sistema glutamatérgico frente ao dano oxidativo causado por ácido quinolínico
(Universidade Federal de Santa Maria, 2013-02-22)
Excessive formation of reactive oxygen species (ROS) and disruption of glutamate
uptake have been hypothesized as key mechanisms contributing to quinolinic acid (QA)-
induced toxicity. Thus, here we investigate if the ...
Efeito protetor do extrato hidroalcoólico de própolis marrom nas lesões vaginais induzidas pelo herpes simples vírus tipo 2
(Universidade Federal de Santa Maria, 2013-01-25)
Propolis is a natural compound and has been highlighted for its antioxidant, antiinflammatory
and antiviral properties. The purpose of this study was to investigate if
brown hydroalcoholic propolis extract (HPE) protects ...
Efeito da espermidina sobre a persistência da memória em ratos
(Universidade Federal de Santa Maria, 2013-02-22)
The long-term memory involves three stages: acquisition, consolidation and extinction. However was recently described a new phase of consolidation, called the persistence of memory. At this stage, crucial events occur 12 ...
Efeito do guaraná (Paullinia cupana) no metabolismo de nucleotídeos e nucleosídeo de adenina em um modelo experimental de hipercolesterolemia
(Universidade Federal de Santa Maria, 2013-08-09)
Hypercholesterolemia is a metabolic disease characterized by high levels of serum low density lipoproteins and total cholesterol, associated with the inflammatory disorders, the migration of monocytes and T cells and with ...
Envolvimento do sistema dopaminérgico na ação do tipo antidepressiva do fenilselenometil em camundongos fêmeas
(Universidade Federal de Santa Maria, 2013-08-05)
Depression affects millions of people of different ages, races, religions and income at some period of their lives. The etiology of most mood disorders, although not fully understood, has come into sharper focus in the ...
Estudos teóricos e de modelagem molecular in silico aplicados à interação entre a enzima delta-aminolevulinato desidratase e disselenetos de diarila
(Universidade Federal de Santa Maria, 2013-05-06)
Delta-aminolevulinic acid dehydratase (δ-ALA-D) is an essential metalloprotein found in several biological processes, since it is able to catalyze the formation of porphobilinogen (PBG), a precursor monopyrol of tetrapyrroles ...
Avaliação da capacidade do disseleneto de difenila em reduzir a falência hepática aguda induzida por paracetamol em camundongos
(Universidade Federal de Santa Maria, 2013-09-18)
Paracetamol (APAP) is commonly used analgesic and antipyretic, however high doses can induce damage hepatic. The metabolic N-acetyl-p-benzoquinone imine (NAPQI) is responsible for the toxic effects. The accumulation of ...
Desenvolvimento de um método de análise in vitro da capacidade genomodificadora de compostos químicos e sintéticos
(Universidade Federal de Santa Maria, 2013-07-16)
DNA is a molecule susceptible to the attack of many toxic substances. So,
studies on the toxic effects of chemical are very important. Tests that evaluate
substances genomodifier (presenting action genoprotetora or ...
Uncaria tomentosa: adjuvante no tratamento do câncer de mama
(Universidade Federal de Santa Maria, 2013-04-19)
Cat s Claw (Uncaria tomentosa) is a medicinal plant that has been used in the treatment of different diseases, among them, cancer. Studies show its effects in restoring the cellular DNA, in increasing leukocyte fractions, ...
Avaliação in vitro e in vivo da toxicidade do composto 2,2 -disseleneto de ditienila em ratos
(Universidade Federal de Santa Maria, 2013-08-05)
The compound 2,2 -dithienyl diselenide (DTDS), an organoselenium compound with thiophene moieties, has been proven to be a promising antioxidant in vitro and in vivo, as well as an antifungal and antimicrobial agent. ...