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Efeitos do resveratrol na sinalização purinérgica em camundongos expostos ao alumínio
(Universidade Federal de Santa Maria, 2023-09-12)
Aluminum (Al) is a compound found in nature, and is widely used industrially, which means that humans are exposed to it daily. Due to its ability to cross the blood-brain barrier, it can accumulate in the brain in regions ...
História natural de onze rãs neotropicais (anura, leptodactylidae): aspectos etários e ciclo gametogênico
(Universidade Federal de Santa Maria, 2023-08-30)
One of the main objectives of the study of organisms´ life history is to explain the patterns
of life cycle, growth, development, and reproductive investment of species. In this
context, knowing the reproductive cycle ...
Efeito do exercício físico sobre o desenvolvimento de crises convulsivas pós-traumáticas em ratos: o papel da trombina
(Universidade Federal de Santa Maria, 2023-09-29)
Traumatic brain injury (TBI) affects about 69 million people worldwide and is the major cause
of post-traumatic epilepsy (PTE), a structural acquired type of epilepsy where acute seizures
onset can influence the ...
Caracterização do potencial genotóxico de porfirinas de base livre e metaloporfirinas de Zn (II)
(Universidade Federal de Santa Maria, 2023-09-06)
Photodynamic therapy (PDT) is a treatment with several benefits, such as few side
effects, ease of application and possible combination with other treatments. It is based on the
production of reactive oxygen species (ROS) ...
Efeitos comportamentais e endócrinos da exposição na fase embrionária ao etonogestrel em peixe-zebra
(Universidade Federal de Santa Maria, 2023-09-18)
Improper disposal of expired drugs directly into the garbage or sewage systems
without specific treatment increases concentration of these components in wastewater.
Waste from pharmaceutical industries, used in research ...
Prescrição de fármacos inapropriados em idosos hospitalizados: análise da mortalidade e sobrevida
(Universidade Federal de Santa Maria, 2023-09-29)
Introduction: Elderly people (>60 years old) have a high prevalence of chronic noncommunicable diseases (DCNTs), often managed through the daily use of four or more
drugs (polypharmacy). Furthermore, they may present ...
Efeito de diferentes protocolos de treinamento físico em modelo experimental de osteoartrite
(Universidade Federal de Santa Maria, 2023-09-21)
Osteoarthritis is characterized as a chronic and degenerative joint disease, affecting
approximately 50% of the elderly population, being associated with pain and morphological
and biochemical alterations. It is known ...
Avaliação fármaco-toxicológica da molécula JM-20 em Caenorhabditis elegans
(Universidade Federal de Santa Maria, 2023-10-17)
With the discovery of new molecules with pharmaceutical potential, studies examining different mechanisms of action and toxicological aspects emerge. The 3-ethoxycarbonyl-2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1H-pyrido ...
Avaliação da influência da dieta em parâmetros de estresse oxidativo, inflamação e modificações epigenéticas em pacientes com lúpus eritematoso sistêmico
(Universidade Federal de Santa Maria, 2023-10-11)
Exacerbated cellular activation due to autoimmunity in Systemic Lupus Erythematosus (SLE)
can generate an imbalance between antioxidants and pro-oxidants, triggering oxidative stress.
In addition to oxidative stress, ...
Curva dose-resposta do extrato lipofílico composto por clorofilas e carotenoides da microalga Scenedesmus obliquus: papel oxidativo e envolvimento da sinalização purinérgica
(Universidade Federal de Santa Maria, 2023-09-27)
More and more innovative proposals based on bioactive compounds are being presented to
the public. The use of microalgae, such as the species Scenedesmus obliquus, has played
an interesting role in this regard through ...