This work examined the effectiveness of Cu pre-exposition on biochemical and behavioral changes induced by Hg exposure in young rats treated subcutaneously with saline or CuCl2.2H2O (Cu 2.6 mg/kg/day) from 3 to 7 days old ...

Lung cancer has been considered a public health problem since it has become one of the most commonly diagnosed neoplastic diseases and one of the most lethal in the world. This spread of lung cancer in the world population ...

Selenophenes are a promising class of heterocyclic selenium-containing compounds presenting important pharmacological properties. Based on selenium well-described role on mood regulation and since depression is a serious ...

Cadmium (Cd) is considered one of the most toxic heavy metals for its ability to affect different tissues, including the brain and the immune system. The molecular mechanisms of toxicity of Cd are not well established, ...

Diphenyl ditelluride (PhTe)2 is an organic tellurium compound widely used as an intermediate in organic synthesis reactions and in the industry. Several studies have shown that this compound causes various toxic effects ...

Brazil nut (Bertholletia excelsa, Lecythidaceae family) is the richest known food in selenium. Its consumption has demonstrated efficient in improving the lipid profile and the plasmatic selenium levels as well as to ...

Hypertension is a multifactor clinical condition, which is accompanied by a low-grade inflammation and alterations in platelet function. These modifications may be related to an imbalance in the regulation of adenine ...

Gout, or gouty arthritis, has been associated of a range of comorbidities as hypertension and kidney diseases. Some studies have indicated that certain antihypertensive drugs, such as angiotensin I-converting enzyme ...

Hypothyroidism is characterized by a disorder resulting from deficiency of thyroid hormones and is related to lipid metabolism dysfunction and cardiovascular diseases development risk. However, these changes in hypothyroidism ...

Recently, oxidative stress was indicated as modulator of nociceptive transmission at spinal cord, and that nitric oxide (NO) may activate the TRPV1 in vitro. As no protein thiol compounds (SH) are the main endogenous ...