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Desenvolvimento e validação de métodos analíticos para o doseamento de daptomicina injetável
(Universidade Federal de Santa Maria, 2013-08-30)
This work presents the development and validation of analytical methods to assay daptomycin injection. Daptomycin is a drug of a new class of antibiotics, known as cyclic lipopeptides. It was approved in USA in 2003 and ...
Associação entre biomarcadores oxidativos, inflamatórios e de disfunção endotelial em pacientes obesos
(Universidade Federal de Santa Maria, 2013-03-25)
Obesity is a world phenomenon caracterized as a cronic metabolic disorder, where the
excess of adipose tissue is responsable for oxidative stress, inflammation and endothelial
dysfunction states. Due the higher number ...
Desenvolvimento tecnológico de produtos secos redispersíveis a partir de nanoestruturas contendo tioconazol
(Universidade Federal de Santa Maria, 2013-04-29)
Spray-drying and freeze-drying are dehydration techniques which serve as alternative to increase the stability of formulations which are in aqueous medium. Therefore, this study objectived the development of redispersible ...
Interações de agentes antifúngicos e antibacterianos frente a Cryptococcus neoformans antes e após indução capsular
(Universidade Federal de Santa Maria, 2013-07-18)
The genus Cryptococcus consists of encapsulated yeasts that cause mainly
cryptococcal meningoencephalitis in immunocompromised patients. This mycosis shows high
percentage of morbidity and mortality. The fault is not the ...
Desonida: desenvolvimento e estudo de estabilidade de formulações de uso tópico
(Universidade Federal de Santa Maria, 2013-10-09)
Desonide is a corticoid used topically in the treatment of dermatological diseases
of inflammatory or allergic origin. In Brazil, is available as cream (0.05%), creamy lotion
(0.05%), gel cream (0.05%), ointment (0.05%) ...
Desenvolvimento de metodologia para avaliação da liberação in vitro e controle de qualidade de diclofenaco potássico suspensão oral
(Universidade Federal de Santa Maria, 2013-01-16)
The diclofenac potassium (DPt) is a derivate of phenylacetic acid, with proprietary anti-inflammatory, analgesic and antipyretic, thus indicated for the relief of low back pain, rheumatoid arthritis and postoperative pain. ...
Prevalência e perfil de sensibilidade de Staphylococcus aureus resistentes à meticilina (MRSA) no Hospital Universitário de Santa Maria
(Universidade Federal de Santa Maria, 2013-08-23)
Methicillin-resistant Staphylococcus aureus (MRSA) are reported worldwide as a high prevalence of pathogens in the etiology of infections, both nosocomial and community. This study aimed to determine the prevalence of MRSA ...
Correlação entre citotoxicidade, alterações cromossômicas e atividade antibacteriana de compostos triazenos em células de medula óssea
(Universidade Federal de Santa Maria, 2013-08-23)
Leukemias are a heterogeneous group of hematologic malignancies. The treatment of these neoplasms has been a challenge to the scientific community due to genetic diversity in leukemic cells. Acquired chromosomal abnormalities ...
Desenvolvimento e validação de método por cromatografia líquida em fase reversa para análise de febuxostate
(Universidade Federal de Santa Maria, 2013-07-25)
Febuxostat is a novel non purine drug indicated for the treatment of hyperuricemia in gout. A reversed-phase liquid chromatography (RP-LC) method was validated for the determination of febuxostat in pharmaceutical dosage ...
Avaliação fitoquímica, capacidade antioxidante e fotoprotetora do extrato e formulações de Calendula officinalis L.
(Universidade Federal de Santa Maria, 2013-12-16)
There are many factors related to oxidative stress, one of which is exposure to ultraviolet
(UV) radiation, which generates reactive oxygen species (ROS). Calendula officinalis L.
presents phenolic compounds, saponins, ...