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Efeitos do difenil disseleneto sobre a disfunção mitocondrial na insuficiência hepática aguda induzida por paracetamol em camundongos
(Universidade Federal de Santa Maria, 2015-02-26)
Acute liver failure (ALF) induced by acetaminophen (APAP) is a complex process associated
with glutathione (GSH) depletion, energetics metabolism changes and mitochondrial dysfunction,
resulting in the impairment of ...
Avaliação do potencial antioxidante e antibacteriano de Anacardium microcarpum e sua toxicidade em diferentes modelos biológicos in vitro
(Universidade Federal de Santa Maria, 2015-09-11)
Oxidative stress reflects an imbalance between the systemic manifestation of reactive species and a biological system s ability to readily detoxify the reactive intermediates or to repair the resulting damage. This condition ...
Efeito protetor do extrato de lingonberry sobre o sistema purinérgico e estresse oxidativos no sistema nervoso de ratos diabéticos
(Universidade Federal de Santa Maria, 2015-10-23)
Diabetes mellitus (DM) is considered a metabolic disorder that affects large part of worldwide. The hyperglycemia of diabetes cause cognitive impairments associated with physiological and structural changes in the central ...
Mecanismos envolvidos na proteção do disseleneto de difenila sobre a toxicidade induzida por metilmercúrio em Saccharomyces cerevisiae
(Universidade Federal de Santa Maria, 2015-12-14)
Humans are usually exposed to organic form of mercury, the organometallic cation methylmercury ([CH3Hg]+, MeHg), by eating fish and seafood. The neurotoxic effects of MeHg are already widely known. Individuals exposed to ...
Melhora dos marcadores sanguíneos inflamatórios em pacientes com hipotireoidismo em tratamento com levotiroxina
(Universidade Federal de Santa Maria, 2015-04-17)
Introduction: Some studies suggest that patients with hypothyroidism have systemic inflammation and increased oxidative stress and consider these factors may contribute to the increased risk of atherosclerosis and ...
Associação entre o consumo de antocianinas e a prevenção de alterações cognitivas, neuroquímicas e inflamatórias nos modelos experimentais de desmielinização e de neuroinflamação em roedores
(Universidade Federal de Santa Maria, 2015-08-14)
Anthocyanins (ANT) are phytonutrients with antioxidant and neuroprotective properties. In this context, this study sought evidence of a possible protective effect of ANT on models of demyelination and neuroinflammation in ...
Estudo toxicológico comparativo referente ao haloperidol na sua forma livre e nanoencapsulada
(Universidade Federal de Santa Maria, 2015-08-14)
The association of haloperidol (HP) with polymeric nanocapsules causes a significant improve in therapeutic efficacy prolongs the drug time of action and reduces motor side effects in rats. However, in view of the HP ...
Mecanismos de toxicidade de Duguetia furfuraceae A. St.-Hill no modelo de Drosophila melanogaster e avaliação do potencial antifúngico.
(Universidade Federal de Santa Maria, 2015-12-04)
Duguetia furfuracea is a common shrub from Brazilian cerrado areas, known as "ata brava", often used as a medicinal plant especially in treatment of renal colic and rheumatism. However, pharmacological studies with extracts ...
Interação entre silício e alumínio em genótipos de batata (Solanum tuberosum L.).
(Universidade Federal de Santa Maria, 2015-03-06)
Silicon (Si) and aluminum (Al) are among the three most abundant elements in the earth's crust. The Si does not meet the requirements of an essential element for plant growth, but the beneficial effects of this element in ...
Silimarina modifica a atividade da Na+/K+-ATPase e da MAO e modula a ação de antimicrobianos in vitro
(Universidade Federal de Santa Maria, 2015-06-10)
The Silymarin is a flavonolignan complex isolated from milk thistle seeds of Silybum marianum being used in the treatment of injury related to oxidative stress, including liver and neurological diseases, as Parkinson ...