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4,4'-dicloro-difenil disseleneto reverte o déficit de memória induzido pela corticosterona em camundongos
(Universidade Federal de Santa Maria, 2016-02-29)
Chronic stress or even a single serious traumatic experience may have a negative impact on cognitive function. In this sense, organic selenium compounds are molecules that arouse great interest because they have various ...
Selenito de sódio previne neurotoxicidade induzida por paraquat em peixe-zebra (Danio rerio)
(Universidade Federal de Santa Maria, 2016-08-26)
Considering the sodium selenite (Na2SeO3) antioxidant properties and the involvement of oxidative and nitrosative stress events in neurotoxicity induced by paraquat (PQ) herbicide, this study investigated the potential ...
3-(4-Fluorofenilselenil)-2,5 difenilselenofeno produz ação do tipo-antidepressiva em diferentes modelos de depressão em camundongos
(Universidade Federal de Santa Maria, 2014-03-11)
Selenophenes are a promising class of heterocyclic selenium-containing compounds
presenting important pharmacological properties. Based on selenium well-described role on
mood regulation and since depression is a serious ...
Hepato- and reno-protective effects of synthetic organoselenium compound, binaphthyl diselenide, against chemical-induced oxidative stress
(Universidade Federal de Santa Maria, 2010-06-16)
The liver presents extraordinary functional diversity, particularly in the control of energy
production, immune defense and volemic reserve. The human being is exposed
occupationally and in the environment to a variety ...
Envolvimento dos sistemas serotoninérgico e opióide na ação do tipo antidepressiva do disseleneto de M-trifluormetilfenila em camundongos
(Universidade Federal de Santa Maria, 2012-08-10)
Serotonergic and opioid systems have been implicated in major depression and in the
action mechanism of antidepressants. The organoselenium compound m-trifluoromethyldiphenyl
diselenide (m CF3 PhSe)2 shows antioxidant ...
2,2'-Disseleneto de ditienila, um composto orgânico de selênio com atividade antioxidante e neuroprotetora em ratos
(Universidade Federal de Santa Maria, 2012-03-02)
Oxidative stress has been implicated in the pathophysiology of several neurological
diseases since the brain is an organ highly susceptible to oxidative damage. Temporal lobe
epilepsy (TLE) has been widely studied due ...
Efeitos dos compostos de selênio e zinco nas lesões gastrointestinais induzidas por etanol em ratos
(Universidade Federal de Santa Maria, 2012-03-30)
Gastric ulcer is a world widespread illness that affectes a great number of people and it is correlated to life style, food intake, alcohol and smoke in association or not to stress behavior. The lesions are in association ...
Disseleneto de p-metoxi fenila atenua o prejuízo cognitivo e a injúria cerebral em um modelo da doença de Alzheimer em roedores
(Universidade Federal de Santa Maria, 2012-09-17)
Alzheimer s disease (AD) is a progressive neurodegenerative disorder, mainly characterized by memory and intellectual capacity loss. AD is characterized by deposition of amyloid-β peptide, neurofibrillary tangles, ...
Avaliação do potencial antioxidante de beta-selenoaminas
(Universidade Federal de Santa Maria, 2013-02-22)
The antioxidant properties of selenium organic compounds have been largely investigated in the last decades, especially because the oxidative stress is directly related to various chronic-degenerative deseases. However, a ...
Toxicidade de organocalcogênios e seus mecanismos através da expressão gênica em leucócitos humanos
(Universidade Federal de Santa Maria, 2015-02-06)
Selenium (Se) is an essential micronutrient present in selenoproteins on living beins, in the form of the amino acid selenocysteine and selenomethionine. Chemically related to Se, tellurium (Te) has no biological function ...