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Interaction of organodiselenides with sulphydryl groups at the active sites of some thiol containing proteins - in vitro and in vivo mechanistic studies in mammalian models of diabetes
(Universidade Federal de Santa Maria, 2008-04-02)
The present study sought to compare the in vitro antioxidant potentials of a newly synthesized organodiselenide, dicholesteroyl diselenide (DCDS) and diphenyl diselenide (DPDS) and their possible interactions with some ...
Atividade das ectonucleotidases, colinesterase sérica e perfil oxidativo no diabetes melito tipo 2 e hipertensão em humanos
(Universidade Federal de Santa Maria, 2008-03-05)
The increase in the NTPDase and 5'-nucleotidase enzymatic activities, in patients with diabetes and hypertension, unchained the investigation of the possible mechanisms involved in the alterations in ectonucleotidases ...
Efeito da N-acetilcisteína no déficit cognitivo induzido pela estreptozotocina em camundongo
(Universidade Federal de Santa Maria, 2016-07-15)
Cognitive impairment is a mental disorder which is associated with neurodegenerative diseases such as Alzheimer's disease (AD), which is the most common form of dementia. Currently there are no consistent evidence who allow ...
Efeitos do difenil disseleneto sobre a disfunção mitocondrial na insuficiência hepática aguda induzida por paracetamol em camundongos
(Universidade Federal de Santa Maria, 2015-02-26)
Acute liver failure (ALF) induced by acetaminophen (APAP) is a complex process associated
with glutathione (GSH) depletion, energetics metabolism changes and mitochondrial dysfunction,
resulting in the impairment of ...
Efeitos do treinamento aeróbico no processo inflamatório e estresse oxidativo no córtex e músculo e a sua relação com exercícios à exaustão, bem como as adaptações causadas pelo treinamento aeróbico no fígado de ratos
(Universidade Federal de Santa Maria, 2015-01-08)
The regular practice of physical exercise is linked to a good life quality. However, each
physical bout has consequences named reactive oxygen species (ROS) production, low-grade
inflammation, delayed onset muscle soreness ...
Ação da Phα1β, peptídeo purificado do veneno da aranha Phoneutria nigriventer, sobre os efeitos analgésicos e adversos causados pela morfina em camundongos
(Universidade Federal de Santa Maria, 2015-06-19)
Opioids are the most common drugs prescribed worldwide for alleviating moderate to
severe pain. However, the use of opioids is associated with the development of
tolerance to the analgesic effect and potential adverse ...
Toxicidade do mercúrio em ratas virgens, gestantes e lactantes: efeito protetor do zinco e da N-acetilcisteína
(Universidade Federal de Santa Maria, 2016-07-15)
Mercury (Hg) is a divalent metal found liquid at room temperature without biological functions and anthropogenically released in industrial, agricultural activities and burning of fossil fuels. Toxic effects caused by ...
Envolvimento do sistema da tiorredoxina nas alterações induzidas pelo chumbo in vitro e in vivo: implicações na toxicidade do chumbo
(Universidade Federal de Santa Maria, 2011-11-30)
Oxidative stress is an important molecular mechanism of lead (Pb) toxicity. The thioredoxin
system (selenoenzyme thioredoxin reductase-TrxR, thioredoxin protein- Trx and NADPH) is essential
for the antioxidant defense ...
Efeitos da exposição ao cloreto de mercúrio durante a gestação e lactação em ratas wistar e sua prole: parâmetros bioquímicos e distribuição de mercúrio
(Universidade Federal de Santa Maria, 2015-05-08)
The objective of this work was to evaluate the effects of HgCl2 exposure in drinking
water in pregnant and/or lactating rats and their offspring. Still, it evaluated if the HgCl2
intravenous exposure as well as the renal ...
Atividade de ectoenzimas do sistema purinérgico e análise de biomarcadores inflamatórios e de estresse oxidativo em pacientes com câncer de pulmão
(Universidade Federal de Santa Maria, 2014-11-13)
Lung cancer has been considered a public health problem since it has become one of the most commonly diagnosed neoplastic diseases and one of the most lethal in the world. This spread of lung cancer in the world population ...