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Avaliação de novos compostos sobre a atividade de colinesterases em modelos in silico e in vitro
(Universidade Federal de Santa Maria, 2012-06-04)
The enzyme acetylcholinesterase (EC 3.1.1.7, AChE) is responsible to terminate acetylcholine activity in
the terminal nervous junctions with its effector organs or post-synaptic sites. The activity of this enzyme
could ...
Efeitos farmacológicos do disseleneto de difenila em modelos de toxicidade induzida por organofosforados em ratos
(Universidade Federal de Santa Maria, 2012-08-10)
Pesticides are substances used in agricultural areas and public health programs to control pests and disease vectors. Among pesticides, organophosphates (OPs) are considered the most toxic to vertebrates. Diphenyl diselenide ...
Efeitos anti-nociceptivo e anti-edematogênico da glibenclamida em um modelo de gota aguda em ratos
(Universidade Federal de Santa Maria, 2013-02-23)
Gout is one form of inflammatory arthritis, which is caused by the precipitation of crystals of monosodium urate (MSU) in the joints. Acute gout is associated with sudden and painful inflammatory episodes characterized by ...
Compostos 1,2 e 1,4-dicarboxílicos atuam sobre o sistema glutamatérgico e o comportamento de ratos e camundongos
(Universidade Federal de Santa Maria, 2005-07-27)
Glutamatergic receptors are targets for many L-glutamate structure analogues, which cause neurotoxicity. This study investigated the actions of two dicarboxylic compounds, the first had cyclic framework and rigid structure, ...
Mecanismos de captação e toxicidade do metilmercúrio: Envolvimento do sistema glutamatérgico e do cálcio em fatias e mitocôndrias de ratos.
(Universidade Federal de Santa Maria, 2012-01-22)
Methylmercury (MeHg) is a highly toxic environmental contaminant that can be accumulated on several tissues, inducing cellular dysfunction on various organs, especially in the central nervous system (CNS). The mechanisms ...
Poliaminas modulam a memória nas tarefas de medo condicionado e esquiva inibitória em ratos
(Universidade Federal de Santa Maria, 2004-09-03)
The polyamines, spermine, spermidine and putrescine, are a group of aliphatic amines that interact with diverse cellular targets such as nucleic acids and proteins. The polyamines may act as physiological modulators of ...
Interações de cobre e fósforo em acessos de Pfaffia glomerata (Spreng.) Pedersen: efeito no crescimento e rendimento de β-ecdisona
(Universidade Federal de Santa Maria, 2013-03-14)
Pfaffia glomerata (Spregen.) Pedersen stands out as a species of great medical and commercial importance due to its major secondary metabolite β-ecdysone, which content can vary in roots under adverse conditions as nutritional ...
Diversidade e distribuição espacial de Ephemeroptera (Insecta) em riachos do Planalto Sul-rio-grandense, Brasil
(Universidade Federal de Santa Maria, 2015-04-27)
The additive partition diversity has been a promising method to analyze patterns of
diversity in hierarchical studies. Streams are recognized for having a spatial structure
hierarchically organized in increasing scales, ...
Dinâmica espacial, migração e preferência de micro-hábitat de Aegla longirostri bond-buckup e buckup, 1994 (crustacea, anomura, aeglidae)
(Universidade Federal de Santa Maria, 2014-02-25)
Understanding the population dynamic processes is fundamental to access its viability (health). Great part of these processes is closely related to the organism densities in a studied population. These data can reveal how ...
Determinação de HPAs presentes na nutrição parenteral e avaliação da exposição de neonatos através da presença do 1-hidroxipireno na urina
(Universidade Federal de Santa Maria, 2016-10-19)
Carbon black, which has polycyclic aromatic hydrocarbons (PAHs) adsorbed
on its surface, is used in the composition of rubber for pharmaceutical used in
injectable drugs and parenteral formulations such as amino acid ...