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Intervenções teórico-práticas com licenciandos em química por meio de problemas temáticos.
(Universidade Federal de Santa Maria, 2020-01-17)
This work presents a didactic strategy developed in the initial teaching formation in Chemistry, through the articulation between the Methodology of Resolution of Problems and Thematic, which was called Thematic Problems. ...
A melhora da consolidação da memória induzida por espermidina envolve a ativação da via PI3K/AKT
(Universidade Federal de Santa Maria, 2020-10-28)
Memory consolidation is a process that depends on specific brain structures, such as the hippocampus, synthesis of new proteins, activation of protein kinases and neurotrophins, such as the brain-derived neurotrophic factor ...
Fenótipos envolvidos em comorbidades associadas às crises convulsivas: abordagens experimentais utilizando o peixe-zebra como organismo modelo
(Universidade Federal de Santa Maria, 2021-02-26)
Epilepsy is a neurological disease characterized by recurrent seizures that affects the cerebral homeostasis. This disease can generate negative consequences for the patient, such as behavioral and cognitive changes. ...
Alterações comportamentais mediadas pelo etanol em peixe-zebra: influência do estresse oxidativo, disfunção mitocondrial e modulação serotoninérgica
(Universidade Federal de Santa Maria, 2020-07-24)
Ethanol consumption is a serious public health problem due to the negative impacts that affect individuals and society. Because the mechanism of action of ethanol in the central nervous system is complex and not fully ...
O disseleneto de difenila protege o modelo Caenorhabditis elegans para a doença de huntington através da ativação antioxidantes reduzindo a agregação de proteínas
(Universidade Federal de Santa Maria, 2020-06-16)
Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disease with a distinct phenotype, including chorea and dystonia, incoordination, cognitive decline and behavioral difficulties. Characterized ...
Estudos in silico aplicados a compostos orgânicos de mercúrio e selênio em sistemas biológicos
(Universidade Federal de Santa Maria, 2020-08-10)
Methylmercury (MeHg) is a potent neurotoxin, which is associated with the inhibition of Glutathione Peroxidase (GPx) and Thioredoxin Reductase (TrxR) selenozymes, however, the mechanism of MeHg inhibition, at the molecular ...
Adição do óleo de Melaleuca alternifolia na dieta de peixes minimiza efeitos tóxicos causados pelo consumo diário de aflatoxina
(Universidade Federal de Santa Maria, 2020-04-09)
Mycotoxins are natural toxins produced through the secondary metabolism of toxigenic fungi. More than 400 classes of mycotoxins are found, however, as aflatoxins (AFs), produced mainly by Aspergillus species, including ...
Depressão e prejuízo de memória induzidos pela administração de estreptozotocina em camundongos: efeitos terapêuticos do disseleneto de p-clorodifenila
(Universidade Federal de Santa Maria, 2020-02-20)
Pre-diabetes and diabetes are metabolic diseases of heterogeneous etiopathology including defects in
the secretion and action of insulin, or both, the presence of hyperglycemia, glucose and insulin
intolerance, disorders ...
JM-20 como composto multialvo: avaliação do potencial antioxidante, inibidor de colinesterases e citotoxicidade
(Universidade Federal de Santa Maria, 2020-10-29)
Multi-target compounds have aroused the interest of many researchers. The main characteristic of these substances is the ability to act through different mechanisms of action, a relevant fact in cases of pathologies caused ...
Disfunção imune em indivíduos HIV positivos sob terapia antirretroviral: papel da razão CD4/CD8 e da atividade da enzima adenosina desaminase
(Universidade Federal de Santa Maria, 2021-03-31)
Human immunodeficiency virus (HIV) uncontrolled replication results in the Acquired
Immunodeficiency Syndrome (AIDS). Antiretroviral therapy (ART) reduces morbidity
and mortality but inflammation and immune activation ...