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Disseleneto m-trifluormetil difenila atenua as fases da sensibilização motora comportamental induzidas por morfina em camundongos
(Universidade Federal de Santa Maria, 2022-02-11)
m-Trifluoromethyl-diphenyldiselenide (m-CF3-PhSe)2 has multiple targets, including the glutamatergic system and the opioid, in addition to having antioxidant properties. Behavioral locomotor sensitization, characterized ...
Influência do sexo nas diferenças comportamentais promovidas pela exposição ao etanol em peixes-zebra submetidos à interação com um objeto não familiar
(Universidade Federal de Santa Maria, 2021-12-16)
In humans, ethanol (EtOH) modulates behavioral functions in a biphasic manner, ranging from disinhibition to sedation. The effects of EtOH are dose-dependent and influenced by environmental and individual factors, such as ...
Efeito neuroprotetor do JM-20 em ratos submetidos a traumatismo cranioencefálico leve
(Universidade Federal de Santa Maria, 2021-09-10)
Traumatic brain injury (TBI) is a multisystemic pathology with interactions between central nervous system, peripheral nervous system and immune system. It is one of the main causes of death and desability worldwide. The ...
Influência do sistema adrenérgico na enzima Na+, K+- ATPase no aparecimento de fadiga em córtex de ratos
(Universidade Federal de Santa Maria, 2021-10-07)
Physical exercise brings health benefits, such as reducing neurological diseases and improving the immune system. Although exercise brings such benefits, it is also a stressor for the body, and may impact the immune and ...
Caracterização enzimática da e-ntpdase em linfócitos residentes de orgãos imunes primários, secundários e não imunes de ratos wistar
(Universidade Federal de Santa Maria, 2021-09-03)
Ectoenzymes play an important role in controlling the signaling developed by adenine nucleotides and nucleosides in countless cells. However, little information is found in the scientific literature about the biochemical ...
Efeitos do glifosato sobre o desenvolvimento embrionário, larval e adulto do peixe-zebra (Danio rerio)
(Universidade Federal de Santa Maria, 2021-09-16)
Glyphosate-Based Herbicides (GBH) are the most used pesticides in the world and pose risks to environmental health and to non-target organisms. This work aimed to verify the toxicity, the mechanisms involved and the ...
Mecanismos neurológicos e sistêmicos envolvidos na patogênese da listeriose e impactos do uso de curcumina livre e nanoencapsulada na infecção in vivo
(Universidade Federal de Santa Maria, 2021-10-27)
Foodborne zoonotic disease, listeriosis contains numerous gaps in knowledge regarding its pathogenic mechanisms. In addition, the problem of bacterial resistance requires potential alternatives to treatment. The aim of ...
Efeitos da curcumina sobre células neurais, diferenciação neural e sinalização purinérgica em embriões de camundongos com toxoplasmose
(Universidade Federal de Santa Maria, 2022-01-26)
Toxoplasmosis is a parasitic disease caused by the obligate intracellular protozoan Toxoplasma gondii. Its characteristics of encystment and persistence, preferably in the central nervous system of mammals, are worrying, ...
Avaliação dos efeitos do consumo de uma dieta rica em sacarose em Drosophila melanogaster: ênfase em alterações metabólicas e transcricionais
(Universidade Federal de Santa Maria, 2021-11-09)
The prevalence of diabetes mellitus (DM) has increased in the last decades, with 90% of cases been of type-2 diabetes (T2D), which is characterized by insulin resistance. In addition to hyperglycemia, T2D is strongly ...
Mecanismos neuroinflamatórios in vitro do alumínio em células microgliais: envolvimento da via de sinalização purinérgica
(Universidade Federal de Santa Maria, 2021-11-09)
Aluminum is a toxic metal to the nervous tissue and an etiological factor of neurodegenerative diseases, particularly Alzheimer's disease (AD). Furthermore, microglial cells and cellular signaling pathways, such as the ...