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Desenvolvimento e validação de métodos cromatográficos para avaliação de interferon-alfa 2a em formulações farmacêuticas
(Universidade Federal de Santa Maria, 2009-03-17)
The interferon is a cytokine with antiviral, antiproliferative, and immunomodulatory
properties. It is a protein synthesized by cells in response to viral infection, producing successive
biochemistry alterations. The ...
Potencial antidepressivo e analgésico do 2-(3,4-dimetoxi-fenil)-4,5-diidro-1H-imidazol (2-DMPI) em camundongos
(Universidade Federal de Santa Maria, 2012-12-18)
Depression and chronic pain coexist in several patients and may be modulated by the same neurotransmitter systems. In this context, various studies have demonstrated that antidepressants from the class of the inhibitors ...
Avaliação de potência de toxina botulínica tipo a por ensaios biológicos e método por cromatografia líquida em fase reversa
(Universidade Federal de Santa Maria, 2015-02-26)
Botulinum toxin type A (BTTA) is a polypeptide with 1296 amino acids and its used in some pathologies like hyperhidrosis and migraine, but the cosmetic area is the most important application. BTTA is produced from broth-culture ...
Prostaglandina E2 potencializa as convulsões induzidas por metilmalonato
(Universidade Federal de Santa Maria, 2009-11-23)
Methylmalonic acidemias comprehend a group of innate error of the metabolism (EIM)characterized clinically and biochemically for the tissue accumulation of acid methylmalonic (MMA)and neurological dysfunction, including ...
Composição química e atividades biológicas de Ocimum gratissimum L.
(Universidade Federal de Santa Maria, 2009-03-31)
Ocimum gratissimum L. (Lamiaceae), known as alfavaca, is widely distributed in tropical and
warm-temperature regions. It is used as a food flavoring and for medicinal purposes against
infectious diseases. Its biological ...
Avaliação da atividade de três compostos do óleo de melaleuca sobre o Trypanosoma evansi
(Universidade Federal de Santa Maria, 2016-02-15)
This study aimed the evaluation of the trypanocidal activity of terpinen-4-ol, γ-terpinene and α-terpinene against Trypanosoma evansi in vivo and in vitro. The in vitro assay was performed in culture medium of T. evansi, ...
Avaliação das toxicidades do suco do fruto de Plinia cauliflora em ratos Wistar
(Universidade Federal de Santa Maria, 2020-12-07)
Plants have always been an essential item for human life, being used as raw material, food, and medicine alike. Even today, with all the developments in medicine, plants are still a fundamental source of solutions. Given ...
Compostos voláteis como sedativos, anestésicos e antinociceptivos em peixes
(Universidade Federal de Santa Maria, 2020-02-18)
Natural products are a drug discovery source for both humans and veterinary treatment. Consequently, in the last decade, essential oils have been researched as fish anesthetics and sedatives, however, there are a small ...
Avaliação da exposição in vivo ao formaldeído sobre parâmetros do estresse oxidativo, inflamação e modificações epigenéticas
(Universidade Federal de Santa Maria, 2020-10-23)
Air quality has been discussed for some time among the scientific community. Air pollution in the external environment and that of the indoor environment have been caused for concern. Volatile organic compounds (VOCs) are ...
Efeitos do tratamento com ácido gálico sobre parâmetros oxidativos, moleculares e comportamentais induzidos por cetamina em ratos
(Universidade Federal de Santa Maria, 2019-12-20)
Ketamine is a dissociative anesthetic drug, which blocks NMDA glutamatergic receptors for restricted clinical use due to its high addictive potential. Studies have shown neurotoxicity and memory impairments development ...