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Avaliação toxicológica de compostos orgânicos de telúrio sobre o desenvolvimento pré-natal em camundongos
(Universidade Federal de Santa Maria, 2011-03-25)
It is known that most chemical agents readily cross the placenta and thus may be considered that maternal exposure to external agents can result in toxic effects on embryo-fetal organism. Considering the chemical characteristics ...
Respostas bioquímicas em carpas (Cyprinus carpio) expostas ao fungicida tebuconazole (folicur® 200 ec)
(Universidade Federal de Santa Maria, 2010-07-22)
The intensive use and/or inadequate management of pesticides have led to contamination of the aquatic ecosystem, reaching the biota living there, including the fish. Pesticides can affect toxicological parameters these ...
Avaliação dos efeitos biológicos do (s) (3-feniltelanil propanamida) succinato de dimetila, um novo telúrio aminoácido derivado do ácido aspártico
(Universidade Federal de Santa Maria, 2011-03-25)
Recent studies from our group demonstrated that the (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate compound, a telluroamino acid showed glutathione peroxidase (GPx)-like activity, attesting to its antioxidant ...
Avaliação dos mecanismos de toxicidade do disseleneto de difenila (PhSe)2 e cloreto de fenilselênio zinco (PhSeZnCl) em Saccharomyces cerevisiae
(Universidade Federal de Santa Maria, 2015-08-21)
Selenium (Se) is a microelement present in different animal tissues in the form of selenoproteins, for example, the glutathione peroxidase (GPx). Organic selenium compounds, such as diphenyl diselenide (PhSe)2 and fenilselenium ...
Avaliação da ação anorexígena do 4, 4’-dicloro difenil disseleneto em ratos
(Universidade Federal de Santa Maria, 2015-04-30)
Obesity is an ever-increasing health concern of global importance. Despite that, treatment options remain limited leading to a constant search for therapies well tolerated and efficacious. Based on several biological actions ...
Desenvolvimento de nanocápsulas contendo disseleneto de bis (p-metoxifenila): biodistribuição e efeitos em modelos de dor em camundongos
(Universidade Federal de Santa Maria, 2017-08-11)
The chronic pain is a global public health problem and its pharmacological management is still unsatisfactory. The identification of novel molecules to effectively treat chronic pain states remains a major objective in ...
Efeito toxicogenético do polimorfismo Ala16Val do gene MnSOD em leucócitos expostos in vitro ao metil mercúrio
(Universidade Federal de Santa Maria, 2012-03-19)
The environmental contamination by methyl mercury (MeHg) is a great health public problem in
some world regions like Amazonia. The MeHg toxic effects seem to be influenced by
environmental and genetic factors. However, ...
Efeitos da adição de alumínio, silício e selênio na fisiologia e bioquímica de Schinus terebinthifolius Raddi
(Universidade Federal de Santa Maria, 2019-03-11)
Brazilian Southern region presents acidic soils, being many of them classified as aluminum and
alicytes, highlighting aluminum (Al) high levels occurrence. When in acid soils, the element is
present in a trivalent ...
JM-20 como composto multialvo: avaliação do potencial antioxidante, inibidor de colinesterases e citotoxicidade
(Universidade Federal de Santa Maria, 2020-10-29)
Multi-target compounds have aroused the interest of many researchers. The main characteristic of these substances is the ability to act through different mechanisms of action, a relevant fact in cases of pathologies caused ...
Parâmetros moleculares e bioquímicos sobre a exposição per os aguda e crônica a xenobióticos eletrofílicos em insetos-modelos
(Universidade Federal de Santa Maria, 2020-08-13)
Continuous exposure to small doses of toxic substances elicit changes in the transcriptional profile and function of proteins before causing physical damage to organisms. Toxic effects can appear even after exposure stops. ...