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Avaliação dos efeitos de compostos orgânicos de selênio e de telúrio sobre a integridade estrutural e funcional de células sangüíneas humanas
(Universidade Federal de Santa Maria, 2009-01-09)
In view of the need to expand the toxicologic studies of organochalcogens in biological systems, the aim of this study was to investigate the effect of exposure to
organic compounds of selenium (Se) and tellurium (Te) on ...
Avaliação dos mecanismos de toxicidade do disseleneto de difenila (PhSe)2 e cloreto de fenilselênio zinco (PhSeZnCl) em Saccharomyces cerevisiae
(Universidade Federal de Santa Maria, 2015-08-21)
Selenium (Se) is a microelement present in different animal tissues in the form of selenoproteins, for example, the glutathione peroxidase (GPx). Organic selenium compounds, such as diphenyl diselenide (PhSe)2 and fenilselenium ...
Efeitos do disseleneto de difenila em carpas expostas a uma formulação comercial contendo cipermetrina e clorpirifós
(Universidade Federal de Santa Maria, 2016-03-11)
Agricultural activity is one of the main factors that lead to the increase of contaminants in aquatic ecosystems and may cause oxidative stress in fish. The objective of this work was to verify the protective effects of ...
Alterações sexo-específicas na memória e homeostase glutamatérgica induzidas por bisfenol A em camundongos: efeito do disseleneto de difenila
(Universidade Federal de Santa Maria, 2017-03-03)
Bisphenol A (BFA) is an endocrine disruptor with high toxicological potential, used in the manufacture of
synthetic polymers, including food and beverage packaging. Even though the deleterious effects of BPA
exposure ...
Disseleneto de m-trifluormetil-difenila modula as adaptações neurotóxicas e comportamentais induzidas pela retirada da morfina em camundongos
(Universidade Federal de Santa Maria, 2019-02-22)
Repeated use of morphine is controversial because it leads to the development of withdrawal syndrome, phenomenon involving a number of neuronal adaptations, which results on manifestations of physical signs and a state ...
Efeito do disseleneto de m-trifluormetil difenila em modelos de dor inflamatória aguda e subcrônica em camundongos
(Universidade Federal de Santa Maria, 2019-02-21)
The inflammation is a multicelular and complex process that has an essential protective role in the
body. However, it can become pathological when it acts with excessive intensity and prolong ...
O disseleneto de difenila protege o modelo Caenorhabditis elegans para a doença de huntington através da ativação antioxidantes reduzindo a agregação de proteínas
(Universidade Federal de Santa Maria, 2020-06-16)
Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disease with a distinct phenotype, including chorea and dystonia, incoordination, cognitive decline and behavioral difficulties. Characterized ...
Caracterização dos genes que codificam selenoproteínas em peixe-zebra (Danio rerio)
(Universidade Federal de Santa Maria, 2020-02-21)
Selenoproteins are selenocysteine (Sec)-containing proteins that exhibit numerous physiological functions, including redox homeostasis maintenance, thyroid hormones metabolism, selenium transport and chaperone-like activities. ...
Envolvimento do sistema dopaminérgico na ação do tipo antidepressiva do fenilselenometil em camundongos fêmeas
(Universidade Federal de Santa Maria, 2013-08-05)
Depression affects millions of people of different ages, races, religions and income at some period of their lives. The etiology of most mood disorders, although not fully understood, has come into sharper focus in the ...
Efeito inibitório do Ebselen, do disseleneto de difenila e do ditelureto de difenila sobre a atividade da LDH de mamíferos
(Universidade Federal de Santa Maria, 2009-02-09)
Ebselen is a seleno compound whose antioxidant properties have been
attributed to its thiol-peroxidase and thioredoxin-like activity: it decomposes
peroxides at the expense of reduced thiols. However, the excessive ...