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Infecção experimental por Herpesvírus bovino tipo 5 em coelhos: efeitos no sistema purinérgico e perfil oxidativo
(Universidade Federal de Santa Maria, 2015-02-12)
The neurological disorder caused by BoHV-5 replication in the brain of infected animals, in the acute phase, may not be associated with significant histological changes or a significant number of antigen-positive neurons. ...
Efeitos do difenil disseleneto sobre a disfunção mitocondrial na insuficiência hepática aguda induzida por paracetamol em camundongos
(Universidade Federal de Santa Maria, 2015-02-26)
Acute liver failure (ALF) induced by acetaminophen (APAP) is a complex process associated
with glutathione (GSH) depletion, energetics metabolism changes and mitochondrial dysfunction,
resulting in the impairment of ...
Avaliação do potencial antioxidante e antibacteriano de Anacardium microcarpum e sua toxicidade em diferentes modelos biológicos in vitro
(Universidade Federal de Santa Maria, 2015-09-11)
Oxidative stress reflects an imbalance between the systemic manifestation of reactive species and a biological system s ability to readily detoxify the reactive intermediates or to repair the resulting damage. This condition ...
Influência da cognição e do metabolismo lipídico-inflamatório-oxidativo no desempenho auditivo de idosos após adaptação de próteses auditivas
(Universidade Federal de Santa Maria, 2015-12-11)
This thesis aimed to track some genetic mutations associated with hearing loss; to assess cognitive status, oxidative stress level, lipid and inflammatory profile also speech perception and auditory processing skills in ...
Melhora dos marcadores sanguíneos inflamatórios em pacientes com hipotireoidismo em tratamento com levotiroxina
(Universidade Federal de Santa Maria, 2015-04-17)
Introduction: Some studies suggest that patients with hypothyroidism have systemic inflammation and increased oxidative stress and consider these factors may contribute to the increased risk of atherosclerosis and ...
Associação entre o consumo de antocianinas e a prevenção de alterações cognitivas, neuroquímicas e inflamatórias nos modelos experimentais de desmielinização e de neuroinflamação em roedores
(Universidade Federal de Santa Maria, 2015-08-14)
Anthocyanins (ANT) are phytonutrients with antioxidant and neuroprotective properties. In this context, this study sought evidence of a possible protective effect of ANT on models of demyelination and neuroinflammation in ...
Mecanismos de toxicidade de Duguetia furfuraceae A. St.-Hill no modelo de Drosophila melanogaster e avaliação do potencial antifúngico.
(Universidade Federal de Santa Maria, 2015-12-04)
Duguetia furfuracea is a common shrub from Brazilian cerrado areas, known as "ata brava", often used as a medicinal plant especially in treatment of renal colic and rheumatism. However, pharmacological studies with extracts ...
Silimarina modifica a atividade da Na+/K+-ATPase e da MAO e modula a ação de antimicrobianos in vitro
(Universidade Federal de Santa Maria, 2015-06-10)
The Silymarin is a flavonolignan complex isolated from milk thistle seeds of Silybum marianum being used in the treatment of injury related to oxidative stress, including liver and neurological diseases, as Parkinson ...
Efeitos da N-acetilcisteína sobre a toxicidade do ditelureto de difenila no encéfalo de camundongos
(Universidade Federal de Santa Maria, 2015-11-18)
The diphenyl ditelluride (PhTe)2 is one of the most toxic organic compounds of tellurium which can make their use unsafe. The mechanism(s) involved in (PhTe)2 toxicity is(are) elusive, but thiol oxidation of critical ...
Efeito protetor da N-acetilcisteína sobre o estresse oxidativo causado pela administração crônica de aspartame em ratos
(Universidade Federal de Santa Maria, 2015-03-12)
This thesis evaluated the N-acetylcysteine effects (150 mg/kg, intraperitoneal) on the
biochemical and oxidative changes caused by the daily oral consumption of aspartame at 40
mg/kg for six weeks by rats. For this ...