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Ação convulsivante do disseleneto de difenila em ratos: estudo dos mecanismos neuroquímicos e da toxicocinética
(Universidade Federal de Santa Maria, 2010-07-27)
In recent years have been identifical numerous pharmacological properties of a selenium compound, diphenyl diselenide [(PhSe)2]. Consequently, it is important the investigation of its toxic effect for a safe application ...
Mecanismos envolvidos nos efeitos do seleneto vinílico bis substituído (svbs) em modelos animais de depressão e de dor
(Universidade Federal de Santa Maria, 2011-03-18)
The association between depression and chronic pain is frequent and bidirectional. The high number of patients with depression and chronic pain who are refractory to currently available drugs makes it important search for ...
Efeito farmacológico do disseleneto de m-trifluormetil-fenila na comorbidade entre dor e depressão em camundongos
(Universidade Federal de Santa Maria, 2015-07-24)
Chronic pain and depression often coexist, and several mechanisms are involved in the pathogenesis of this comorbidity, which confer it resistance to treatment. The serotonergic system is considered a central mechanism in ...
Efeitos metabólicos do consumo da castanha do Brasil (Bertholletia excelsa) em humanos saudáveis
(Universidade Federal de Santa Maria, 2014-02-25)
Brazil nut (Bertholletia excelsa, Lecythidaceae family) is the richest known food in selenium. Its consumption has demonstrated efficient in improving the lipid profile and the plasmatic selenium levels as well as to ...
Ação farmacológica do 3-alquinil selenofeno em modelos de convulsão em ratos jovens
(Universidade Federal de Santa Maria, 2012-03-02)
Seizures have important consequences in terms of mortality and quality of life of the affected population, being a risk factor for the development of cognitive and behavioral abnormalities. Considering the promising ...
Efeitos farmacológicos do disseleneto de difenila em modelos de toxicidade induzida por organofosforados em ratos
(Universidade Federal de Santa Maria, 2012-08-10)
Pesticides are substances used in agricultural areas and public health programs to control pests and disease vectors. Among pesticides, organophosphates (OPs) are considered the most toxic to vertebrates. Diphenyl diselenide ...
O sistema opioide contribui para o efeito do tipo antidepressivo do disseleneto de m-trifluormetil-difenila em camundongos
(Universidade Federal de Santa Maria, 2018-07-20)
Depression is a mental disorder with complex pathophysiology and characterized by multiple symptoms, which makes it difficult to treat this disease. In the last decades, the opioid system has become the focus of depression ...
Avaliação da ação anorexígena do 4, 4’-dicloro difenil disseleneto em ratos
(Universidade Federal de Santa Maria, 2015-04-30)
Obesity is an ever-increasing health concern of global importance. Despite that, treatment options remain limited leading to a constant search for therapies well tolerated and efficacious. Based on several biological actions ...
Disseleneto de difenila em modelos de infecção viral causada por herpes simplex vírus dos tipos 1 e 2
(Universidade Federal de Santa Maria, 2017-03-02)
Infectious diseases caused by herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are among the pathologies that most affect the population. The search for new therapeutic alternatives for its treatment becomes relevant ...
Propriedades antinociceptivas e antioxidantes do disseleneto de bis(fenilimidazoselenazolila) em roedores
(Universidade Federal de Santa Maria, 2016-11-07)
The current available drugs for treatment of disorders related to pain and inflammation present several adverse effects, then the investigation for novel molecules are required. It is known that organoselenium compounds ...