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Atividade antinociceptiva de derivados 5-trifluormetil-4,5-diidro-1h-pirazol-1-carboxiamida em modelos animais de nocicepção aguda e crônica
(Universidade Federal de Santa Maria, 2008-08-06)
To identify the origin of pain and relieve of it is, certainly, important part of the
treatment of any pathology. Unfortunately, nor all pain modalities possess an
adequate treatment at a moment. Many patients do not obtain ...
Avaliação do potencial antinociceptivo de 5- trialometil- 4,5-diidro-1h- pirazol metil ésteres inéditos em camundongos
(Universidade Federal de Santa Maria, 2008-07-11)
Pain is a common symptom in clinical practice and many advances have been observed in order to obtain more effective analgesic molecules with fewer side
effects. The present study evaluated the antinociceptive potential ...
Avaliação do perfil oxidativo e da atividade de ectoenzimas em pacientes com neoplasia intra-epitelial cervical
(Universidade Federal de Santa Maria, 2008-08-22)
Uterine cancers are considered to be one of the most important malignant diseases of the female genital tract, preceded only by breast cancer. The tumor cells may produce oxidative disturbances as well as damage to the ...
Sistemas purinérgico e colinérgico e perfil oxidativo no encéfalo de roedores: influência do alumínio e de diferentes dietas
(Universidade Federal de Santa Maria, 2008-03-05)
In this study, the effects of Aluminium (Al) and of different diets, both individually and in association, were investigated through the determination of NTPDase, 5 -nucleotidase and acetylcholinesterase (AChE) activities ...
Interaction of organodiselenides with sulphydryl groups at the active sites of some thiol containing proteins - in vitro and in vivo mechanistic studies in mammalian models of diabetes
(Universidade Federal de Santa Maria, 2008-04-02)
The present study sought to compare the in vitro antioxidant potentials of a newly synthesized organodiselenide, dicholesteroyl diselenide (DCDS) and diphenyl diselenide (DPDS) and their possible interactions with some ...
Atividade das ectonucleotidases, colinesterase sérica e perfil oxidativo no diabetes melito tipo 2 e hipertensão em humanos
(Universidade Federal de Santa Maria, 2008-03-05)
The increase in the NTPDase and 5'-nucleotidase enzymatic activities, in patients with diabetes and hypertension, unchained the investigation of the possible mechanisms involved in the alterations in ectonucleotidases ...
Caracterização da atividade pró-oxidante de diferentes agentes e estudo do potencial antioxidante de intermediários do ciclo de Krebs sobre alterações oxidativas induzidas in vitro
(Universidade Federal de Santa Maria, 2008-05-02)
Previous data from the literature have shown that some Krebs cycle intermediates could act as antioxidant in several models, both in vitro and in vivo. However, the
mechanism(s) involved in the antioxidant effect of Krebs ...
Avaliação do estresse oxidativo e da atividade da enzima d-aminolevulinato desidratase em pacientes transplantados de medula óssea
(Universidade Federal de Santa Maria, 2008-12-19)
Bone marrow transplantation (BMT) has been used in the treatment of a number of
diseases. Before BMT, patients are submitted to a conditioning regime (CR) that consists of
administration of high doses of chemo- or ...
Papel da recaptação e de metabólitos da dopamina na discinesia orofacial induzida por neurolépticos em ratos
(Universidade Federal de Santa Maria, 2008-05-12)
Fluphenazine-induced orofacial dyskinesia (OD) is a putative animal model of tardive dyskinesia (TD) whose pathophysiology has been related to an increase in
dopamine hypersensitivity and oxidative stress. Data from ...
Parâmetros toxicológicos em piavas (Leporinus obtusidens) e jundiás (Rhamdia quelen) após exposição a uma formulação comercial de glyphosate
(Universidade Federal de Santa Maria, 2008-02-15)
The commercial formulations of glyphosate herbicide have been widely used in agriculture and pisciculture for controlling plant weeds. Fish can be affected when drainage water reaches water courses, causing a disturbance ...