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Estudo da prevalência de hemoglobina S em doadores de sangue na região de Santa Maria-RS e aconselhamento genético familiar
(Universidade Federal de Santa Maria, 2009-02-18)
The Sickle Cell Anemia is the most common monogenic hereditary disease in the
world. The cause of this disease is a changing point in the position six of the beta globin
gene for hemoglobin, changing the glutamic acid ...
Reposicionamento e avaliação da atividade antibacteriana e de clivagem do DNA plasmidial in vitro dos não antibióticos Anlodipino e Valsartana
(Universidade Federal de Santa Maria, 2019-12-19)
Infections caused by multiresistant microrganisms have increased considerably in recent years,
reaching approximately one fifth of worldwide mortality, becoming a public health problem. Another
worrying factor is the ...
Avaliação in vitro da atividade de antimicrobianos na cavidade bucal sobre Candida glabrata sensíveis e resistentes ao fluconazol
(Universidade Federal de Santa Maria, 2016-03-21)
Oropharyngeal candidiasis is a challenging fungal disease in the clinical setting of immunocompromised patients, either by their morbidity or by its difficulties in treatment. Patients with AIDS, cancer, and transplanted ...
Desenvolvimento e validação de métodos cromatográficos para avaliação de teor/potência de insulina glargina
(Universidade Federal de Santa Maria, 2016-03-30)
hans, and is secreted into the bloodstream. It plays and important role in regulating the
metabolic activities of the body, particularly the homeostasis of the blood glucose. Insulin
glargine is a recombinant human insulin ...
Estudo de métodos cromatográficos e ensaio biológico para avaliação do anticorpo monoclonal denosumabe
(Universidade Federal de Santa Maria, 2017-07-27)
Denosumab (DmAb) is a fully human monoclonal antibody that inhibits osteoclast formation, function and survival, reducing bone turnover and resorption. Structurally, it is a fully human immunoglobulin G2, yielding a molecular ...
Avaliação de potência de interferon beta -1b por métodos cromatográficos validados e bioensaio
(Universidade Federal de Santa Maria, 2017-07-27)
Interferon is a cytokine with antiviral, antiproliferative and immunomodulatory properties that influences cell metabolism, growth and differentiation. The recombinant human interferon β 1b (rhIFNβ-1b) is a non-glycosylated ...
Validação de métodos cromatográficos para avaliação de estreptoquinase e correlação com o bioensaio
(Universidade Federal de Santa Maria, 2016-03-30)
The streptokinase (STK) is a secreted and isolated molecule of β-hemolytic streptococci,
consists of 414 amino acids and clinically indicated as a thrombolytic agent for myocardial
infarction, deep vein thrombosis, ...
Desenvolvimento e validação de método por cromatografia líquida em fase reversa para análise de rivaroxabana
(Universidade Federal de Santa Maria, 2015-02-27)
Rivaroxaban is an oral anticoagulant drug indicated for deep venous thromboembolism prophylaxis. A reversed-phase liquid chromatography (RP-LC) method was developed and validated for the determination of rivaroxaban in ...
Análise da atividade dos sais de ferro e desferroxamina na maturação de biofilme de micobactérias de crescimento rápido
(Universidade Federal de Santa Maria, 2022-02-03)
Fast-growing mycobacterial infections have been gradually described in recent years, mainly because they are associated with a wide range of clinical syndromes, ranging from mild diseases to more severe disorders, such as ...
Revisão sistemática sobre dados hematológicos e toxicológicos de doadores de sangue fumantes e não fumantes
(Universidade Federal de Santa Maria, 2022-03-03)
Blood donation is essential for public health, in the routine of hospitals and emergency rooms, hundreds of lives are saved every day with the blood donated by the population. Tobacco use is considered by the World Health ...