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Envolvimento dos sistemas serotoninérgico e opióide na ação do tipo antidepressiva do disseleneto de M-trifluormetilfenila em camundongos
(Universidade Federal de Santa Maria, 2012-08-10)
Serotonergic and opioid systems have been implicated in major depression and in the
action mechanism of antidepressants. The organoselenium compound m-trifluoromethyldiphenyl
diselenide (m CF3 PhSe)2 shows antioxidant ...
Metodologias ativas no ensino de bioquímica: possibilidades e contribuições
(Universidade Federal de Santa Maria, 2023-03-30)
Biochemistry is an interdisciplinary science, present in the curriculum of several higher
education courses. Due to the complexity and abstraction of its concepts, many students
perceive it as a challenging discipline, ...
2,2'-Disseleneto de ditienila, um composto orgânico de selênio com atividade antioxidante e neuroprotetora em ratos
(Universidade Federal de Santa Maria, 2012-03-02)
Oxidative stress has been implicated in the pathophysiology of several neurological
diseases since the brain is an organ highly susceptible to oxidative damage. Temporal lobe
epilepsy (TLE) has been widely studied due ...
Efeitos de diferentes tratamentos com atorvastatina sobre as convulsões induzidas por pentilenotetrazol
(Universidade Federal de Santa Maria, 2011-08-22)
Statins are inhibitors of the 3-hydroxy-3-metil-glutaryl coenzyme A reductase, the rate-limiting enzyme in the pathway for cholesterol synthesis. Several studies have shown that statins, particularly atorvastatin, are ...
Avaliação de parâmetros bioquímicos em jundiás expostos a três formulações comerciais de glifosato
(Universidade Federal de Santa Maria, 2013-08-16)
Due to the increase in food production in the last years, the use of pesticides has also increased significantly. These pesticides pollute aquatic ecosystems and harm non-target organisms, such as fish. Therefore, the aim ...
Estudo da toxicologia e da farmacologia do 2-feniletinilbutil-telúrio em roedores
(Universidade Federal de Santa Maria, 2013-08-05)
The organotellurium compounds have been the subject of research due to their pharmacological and toxicological properties. It is believed that the main mechanism involved in the toxicity of these compounds is the ability ...
Efeitos do exercício físico sobre o processo inflamatório e sobre o déficit motor induzidos pelo traumatismo cranioencefálico em ratos
(Universidade Federal de Santa Maria, 2013-02-21)
Traumatic brain injury (TBI) is a public health problem, and is considered a leading cause of death among children and young adults in industrialized countries. TBI can be defined as a mechanical external aggression to the ...
Avaliação dos sistemas purinérgico e colinérgico no processo inflamatório de pacientes com síndrome metabólica
(Universidade Federal de Santa Maria, 2012-08-28)
Metabolic syndrome (MetS) is characterized by the presence of set cardiovascular risk factors such as hypertension, hyperglycemia, dyslipidemia and abdominal obesity. This pathology has been widely discussed due to the ...
O papel da bioenergética mitocondrial e estresse oxidativo no comportamento depressivo em modelo de concussão recorrente em camundongos
(Universidade Federal de Santa Maria, 2020-10-22)
The traumatic brain injury (TBI) is one lesion occasioned by the mechanical application of a force external to the brain.
Currently, 80 to 90% of cases of TBIs are considered concussion or mild TBI, in which contain the ...
Avaliação do potencial antioxidante de beta-selenoaminas
(Universidade Federal de Santa Maria, 2013-02-22)
The antioxidant properties of selenium organic compounds have been largely investigated in the last decades, especially because the oxidative stress is directly related to various chronic-degenerative deseases. However, a ...